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Physicians' Health Study II

NCT00270647 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 14641

Last updated 2018-02-28

No results posted yet for this study

Summary

The use of vitamin E, vitamin C, beta carotene, and/or multivitamins may keep cancer, cardiovascular disease, eye diseases, or cognitive decline from occurring. This randomized clinical trial studied vitamin E, vitamin C, beta carotene, and/or multivitamins to see how well they work compared with placebos in preventing cancer, cardiovascular disease, eye disease, and cognitive decline in male doctors aged 50 years and older.

Conditions

Interventions

DIETARY_SUPPLEMENT

Vitamin E

400 IU synthetic alpha-tocopherol or its placebo on alternate days (provided by BASF)

DIETARY_SUPPLEMENT

Vitamin C

500 mg synthetic ascorbic acid or its placebo daily (provided by BASF)

DIETARY_SUPPLEMENT

Multivitamin

Centrum Silver or its placebo daily (provided by Pfizer (formerly Wyeth, American Home Products, and Lederle))

DIETARY_SUPPLEMENT

Beta-carotene

50 mg Lurotin or placebo on alternate days (provided by BASF)

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • Brigham and Women's Hospital

    lead OTHER

Principal Investigators

  • J. Michael Gaziano, MD, MPH · Brigham and Women's Hospital

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
FACTORIAL

Eligibility

Min Age
50 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1997-07-31
Primary Completion
2011-06-30
Completion
2011-06-30

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00270647 on ClinicalTrials.gov