Therapeutic Zinc in Childhood Pneumonia

Summary

The aim of this study is to assess whether zinc given as adjuvant therapy to standard antibiotic treatment in children hospitalized for severe pneumonia reduces the duration of the severe illness and risk of treatment failure. A randomized double blind placebo controlled clinical trial will be conducted at the Kanti Hospital.

Conditions

• Pneumonia

Interventions

DRUG

Zinc (zinc sulphate)

Dissolvable zinc tablet 10 mg elemental zinc per day for infants 20 mg elemental zinc per day for children 12 to 35 months

DRUG

Placebo

Placebo

Sponsors & Collaborators

• Tribhuvan University, Nepal

  collaborator OTHER

• Statens Serum Institut

  collaborator OTHER

• All India Institute of Medical Sciences

  collaborator OTHER

• Institut de Recherche pour le Developpement

  collaborator OTHER_GOV

• Society for Applied Studies

  collaborator OTHER

• Centre For International Health

  lead OTHER

Principal Investigators

• Sudha Basnet, MD · Department of Child Health, Institute of Medicine, Tribhuwan University, Katmandu, Nepal

• Tor A Strand, MD, PhD · Centre For International Health

• Halvor Sommerfelt, MD, PhD · Centre For International Health

• Nita Bhandari, MBBS, PhD · Centre For International Health

• Prakash S Shrestha, MD · Child Health Research Project, Department of Child Health, Institute of Medicine, Maharajganj:

• Ramesh K Adhikari, MD · Child Health Research Project, Department of Child Health, Institute of Medicine, Maharajganj:

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

2 Months

Max Age

35 Months

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2006-01-31

Primary Completion

2008-07-31

Completion

2008-07-31

Countries

• Nepal

Study Locations