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The Genetic Basis of Atrial Fibrillation (AF)

NCT00248326 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2016-01-05

No results posted yet for this study

Summary

The investigators' goal with this research is to:

1. Establish a clinical database and a DNA bank for 1000 individuals with AF and 1000 individuals without AF.
2. Directly test the hypothesis that known functional polymorphisms in the coding sequences and the promoter regions of cardiac genes (ion channels and genes known to affect survival in the setting of left ventricular dysfunction) predispose individuals to AF.

Over the past decade, advancing techniques and technologies for gene characterization have yielded significant clues as to the molecular mechanism of certain human heart rhythm disorders. The role of ion channel polymorphisms in subjects with AF is unknown. Similarly, it is also not known whether polymorphisms in other genes have an impact on the risk of AF.

The ability to characterize genomic "at-risk" profiles would have many potential benefits for patient care. Paramount among these is:

1. Increased oversight or intervention of at-risk subjects, which might prevent unnecessary morbidity and mortality due to AF.
2. Further insight into the pathogenesis of AF, which may lead to preventative or curative therapies.

Conditions

Sponsors & Collaborators

  • EP Research funds

    collaborator UNKNOWN

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • David S. Schwartzman, MD · University of Pittsburgh/UPMC

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-01-31
Primary Completion
2010-01-31
Completion
2010-01-31

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00248326 on ClinicalTrials.gov