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Impact of Medical and Surgical Therapy on Functional Mitral Regurgitation

NCT00224809 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 250

Last updated 2014-02-19

No results posted yet for this study

Summary

The Transesophageal Echocardiography (TEE) Surgical Treatment of Ischemic Heart Failure (STICH) ancillary study will define the mechanism(s) of functional mitral regurgitation (MR) by TEE in patients with ischemic cardiomyopathy, and the impact of therapy (medical, coronary artery bypass grafting \[CABG\], or CABG plus surgical ventricular restoration \[SVR\]) on mechanism and severity of MR. Severity of the effect of functional MR on clinical outcomes will also be examined. The TEE STICH study will address four specific aims that will focus on defining the following: 1) the mechanism(s) of functional MR in ischemic cardiomyopathy; 2) the effect of therapy on the mechanism and severity of functional MR; 3) myocardial viability on functional MR and its response to treatment; and 4) the effect of MR on prognosis in ischemic cardiomyopathy.

Conditions

Interventions

DRUG

Angiotensin-Converting Enzyme Inhibitors

PROCEDURE

Coronary Artery Bypass Graft

DRUG

Angiotensin Receptor Blockers

DRUG

Spironolactone

DRUG

Aspirin

DRUG

Clopidogrel

PROCEDURE

Surgical Ventricular Restoration

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • Baylor Research Institute

    lead OTHER

Principal Investigators

  • Paul A. Grayburn · Baylor Research Institute

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Model
FACTORIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2002-09-30
Completion
2007-05-31

Countries

  • United States

Study Locations

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Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00224809 on ClinicalTrials.gov