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Effect of Menstrual Cycle on Central Nervous System (CNS) Processing of Gut Stimuli in Irritable Bowel Syndrome (IBS) and Control

NCT00219531 · Status: TERMINATED · Type: OBSERVATIONAL · Enrollment: 48

Last updated 2017-11-29

No results posted yet for this study

Summary

The hypothesis of the study is that women perceive intestinal stimulation (rectal balloon distention) differently in different phases of the menstrual cycle, i.e there is an effect of hormones on the sensory pathway, and that this difference is reflected in the Central Nervous System processing of this signal. We also hypothesize that there is a difference in perception between control subjects and subjects with the irritable bowel syndrome.

Conditions

  • Irritable Bowel Syndrome

Interventions

BEHAVIORAL

perception of rectal balloon distention

functional Magnetic Resonance Imaging (fMRI) study with measurement of brain MRI response to rectal balloon distention.

Sponsors & Collaborators

  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

    collaborator NIH

  • American College of Gastroenterology

    collaborator OTHER

  • Penn State University

    lead OTHER

Principal Investigators

  • Ann Ouyang, MD · Penn State College of Medicine and Penn State Milton S. Hershey Medical Center

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1999-03-31
Primary Completion
2015-02-28
Completion
2015-02-28

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00219531 on ClinicalTrials.gov