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Efficacy of Fosmidomycin-Clindamycin for Treating Malaria in Gabonese Children

NCT00214643 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 160

Last updated 2009-02-04

No results posted yet for this study

Summary

There is a necessity for the development of new malaria drugs. Some antibiotics are also effective against malaria parasites. Fosmidomycin is an antibiotic that has been shown to be effective against malaria, although it cannot achieve a total cure in all patients. Previous small studies have shown that in combination with clindamycin, an commonly used antibiotic, it is highly effective and safe when given for three days, leading to a total cure in most patients. The current study will evaluate its efficacy in a larger population in Gabon, and compare its effect with the generally used drug, sulfadoxine-pyrimethamine.

Conditions

Interventions

DRUG

Fosmidomycin

30 mg/kg

DRUG

clindamycin

10 mg/kg

Sponsors & Collaborators

  • Albert Schweitzer Hospital

    collaborator OTHER

  • Albert Schweitzer Hospital, Netherlands

    lead UNKNOWN

Principal Investigators

  • Saadou Issifou, MD · Albert Schweitzer Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
3 Years
Max Age
14 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2005-06-30
Completion
2006-07-31

Countries

  • Gabon

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00214643 on ClinicalTrials.gov