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Chloroquine and Amodiaquine for Treatment of Malaria in Children

NCT00137514 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 720

Last updated 2008-04-08

No results posted yet for this study

Summary

This study will evaluate the efficacy of the treatment recommended by the National Malaria Programme in Guinea-Bissau as compared to a higher dose of chloroquine and to another anti-malarial drug, amodiaquine. The genetic basis of the parasites for developing resistance will be examined. Children coming to Bandim Health Centre with symptoms of malaria and a positive malaria test will be included. The children will be visited and malaria films will be obtained weekly until day 35. In case of a reappearance of parasites the children will be re-treated with sulfadoxine/pyrimethamine.

Conditions

  • Malaria, Falciparum

Interventions

DRUG

chloroquine

DRUG

amodiaquine

Sponsors & Collaborators

  • Bandim Health Project

    lead OTHER

Principal Investigators

  • Peter Aaby · Bandim Health Project

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Max Age
15 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2001-03-31
Primary Completion
2004-05-31
Completion
2004-05-31

Countries

  • Guinea-Bissau

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00137514 on ClinicalTrials.gov