Effect of Increased Convective Clearance by On-Line Hemodiafiltration on All Cause Mortality in Chronic Hemodialysis Patients

Summary

The purpose of this study is to compare the effect of low flux hemodialysis with online hemodiafiltration on all cause mortality and a combination of cardiovascular morbidity and mortality in chronic hemodialysis patients.

Conditions

• End-stage Renal Disease
• Cardiovascular Disease

Interventions

PROCEDURE

on-line hemodiafiltration

addition of convective transport to regular dialysis treatment by using on-line hemodiafiltration

PROCEDURE

low flux hemodialysis

standard treatment

Sponsors & Collaborators

• UMC Utrecht

  collaborator OTHER

• Medical Center Alkmaar

  collaborator OTHER

• Maasstad Hospital

  collaborator OTHER

• Julius Center for Health Sciences and Primary Care, Utrecht

  collaborator UNKNOWN

• Dutch Kidney Foundation

  collaborator OTHER

• Fresenius Medical Care North America

  collaborator INDUSTRY

• Gambro Renal Products, Inc.

  collaborator INDUSTRY

• Baxter Healthcare Corporation

  collaborator INDUSTRY

• Roche Pharma AG

  collaborator INDUSTRY

• Amsterdam UMC, location VUmc

  lead OTHER

Principal Investigators

• Menso J Nubé, MD PhD · Medical Center Alkmaar

• Piet M ter Wee, MD PhD · Vrije Universiteit Medical Center, Amsterdam

• Peter J Blankestijn, MD PhD · Universityr Medical Center Utrecht

• René A van den Dorpel, MD PhD · Medisch Centrum Rijnmond Zuid - locatie Clara, Rotterdam

• Michiel L Bots, MD PhD · Julius Center for Health Sciences and Primary Care, Utrecht

• Muriel PC Grooteman, MD PhD · Vrije Universiteit Medical Center, Amsterdam

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2004-06-30

Primary Completion

2010-12-31

Completion

2011-01-31

Countries

• Canada
• Netherlands
• Norway

Study Locations