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Effect of Dialysis Techniques on Blood Pressure and Cardiac Function During Dialysis

NCT03249532 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2021-11-30

No results posted yet for this study

Summary

Online hemodiafiltration confers a reduced mortality risk. However, it is not clear why HDF improved survival. To gain more insight in this issue, the effect of 4 dialysis techniques (differing in dialysate temperature and the absence/presence of convective clearance) on intradialytic hemodynamic stability and cardiac function will be investigated in a prospective cross over trial.

Conditions

  • End Stage Renal Disease (ESRD)
  • Hemodialysis
  • Hemodiafiltration
  • Intradialytic Hypotension
  • Diastolic Dysfunction

Interventions

DEVICE

standard hemodialysis

hemodialysis with high-flux dialyzer; prescription of dialysate temperature: 36.5 degrees Celsius; convection volume: not applicable

DEVICE

cool hemodialysis

hemodialysis with high-flux dialyzer; prescription of dialysate temperature: 35.5 degrees Celsius; convection volume: not applicable

DEVICE

low volume hemodiafiltration

hemodiafiltration; prescription of dialysate temperature: 36.5 degrees celsius prescription of convection volume: 15 L

DEVICE

high volume hemodiafiltration

hemodiafiltration; prescription of dialysate temperature: 36.5 degrees celsius prescription of convection volume: 25 L

Sponsors & Collaborators

  • Niercentrum aan de Amstel, Amstelveen, Netherlands

    collaborator UNKNOWN

  • B.Braun Avitum AG

    collaborator INDUSTRY

  • Amsterdam UMC, location VUmc

    lead OTHER

Principal Investigators

  • Muriel PC Grooteman, MD PhD · Amsterdam UMC, location VUmc

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-06-01
Primary Completion
2021-02-15
Completion
2021-02-15

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03249532 on ClinicalTrials.gov