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Relationship Between Succinate Dehydrogenase Mutations and High-Altitude Illness

NCT00202683 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 83

Last updated 2007-05-17

No results posted yet for this study

Summary

This study is is the first step of a full study named CHEMOGENE because it explores the genetic determinant of an alteration of the chemoreflex. This reflex determines hyperventilation when the pressure of oxygen falls in the blood. This happens when subjects travel to high-altitude where oxygen levels diminish in the atmosphere. Subjects with such an altered chemoreflex are intolerant to altitude and develop pulmonary or cerebral edema associated with a severe headache. In this study we compare subjects tolerant to high altitude (8000 meters)to subjects intolerant to altitude. The chemoreflex is measured i.e. the hyperventilation associated with hypoxia and all subjects are scanned for the genes implicated in the mitochondrial respiratory chain. The idea is that subjects with an impaired oxygen sensing will exhibit an altered chemoreflex and will be intolerant to high-altitude.

Conditions

  • Altitude Intolerance
  • High-Altitude Illness

Sponsors & Collaborators

  • Société Française de Cardiologie

    lead OTHER

Principal Investigators

  • Jean-Luc ELGHOZI, Prof. · Institut National de la Sante et de la Recherche Medicale U 652

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2005-03-31
Completion
2006-12-31

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00202683 on ClinicalTrials.gov