High Dose CHOP in Lymphoma
NCT00192764 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 45
Last updated 2010-09-22
Summary
The study hypothesis is that intensification of CHOP by dose escalation of the most active drugs in the combination will improve treatment outcome. Patients with diffuse large-cell lymphoma are treated by high cyclophosphamide containing CHOP. The planned dose is 3000 mg/m2 which is 4 times the atandard one. Only 4 cycles are given.
Conditions
- Non-Hodgkin's Lymphoma
Interventions
- DRUG
-
high-dose cyclophosphamide
Sponsors & Collaborators
-
Rambam Health Care Campus
lead OTHER
Principal Investigators
-
Ron Epelbaum, MD · nonaffiliated
Study Design
- Allocation
- NON_RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 1996-12-31
- Completion
- 2010-09-30
Countries
- Israel
Study Locations
More Related Trials
-
Dose-Dense Therapy in Aggressive Lymphoma
NCT00517894 ·Status: NO_LONGER_AVAILABLE
-
Aminocamptothecin in Treating Patients With Refractory or Recurrent Hodgkin's Disease or Non-Hodgkin's Lymphoma
NCT00002745 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy in Treating Patients With Aggressive Non-Hodgkin's Lymphoma
NCT00005867 ·Status: COMPLETED ·Phase: PHASE3
-
S9911, Combination Chemotherapy Plus Monoclonal Antibody Therapy in Treating Patients With Non-Hodgkin's Lymphoma
NCT00003784 ·Status: COMPLETED ·Phase: PHASE2
-
Safety Study of Darinaparsin in Combination With Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (CHOP) to Treat Lymphoma
NCT01139359 ·Status: WITHDRAWN ·Phase: PHASE1
-
Combination Chemotherapy & Lenalidomide in Newly Diagnosed Stage II-IV Peripheral T-cell Non-Hodgkin's Lymphoma
NCT02561273 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Aflibercept and Standard Chemotherapy (R-CHOP) in First Line of Non Hodgkin B-cell Lymphoma
NCT00644124 ·Status: COMPLETED ·Phase: PHASE1
-
Phase 1 Dose Finding Study of Belinostat for Treatment of Patients With Peripheral T-cell Lymphoma (PTCL)
NCT01839097 ·Status: COMPLETED ·Phase: PHASE1
-
Study to Evaluate the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic of CC-95775 in Subjects With Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin Lymphoma
NCT04089527 ·Status: COMPLETED ·Phase: PHASE1
-
SAHA + CHOP in Untreated T-cell Non-Hodgkin's Lymphoma
NCT00787527 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Doxorubicin (Doxil) Combined With Rituxan, Cyclophosphamide, Vincristine and Prednisone in Newly Diagnosed Aggressive Non-Hodgkin's Lymphomas
NCT00184002 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase I Study of Intravenous CHO-H01 in Patients With Refractory or Relapsed Follicular Lymphoma
NCT03221348 ·Status: UNKNOWN ·Phase: PHASE1
-
CHOP vs GEM-P in 1st Line Treatment of T-cell Lymphoma, Multicentre Phase II Study
NCT01719835 ·Status: UNKNOWN ·Phase: PHASE2
-
Clinical Trial of Chidamide Combined With CHOP in Peripheral T-cell Lymphoma Patients
NCT02809573 ·Status: COMPLETED ·Phase: PHASE1
-
Intravenous Chemotherapy or Oral Chemotherapy in Treating Patients With Previously Untreated Stage III-IV HIV-Associated Non-Hodgkin Lymphoma
NCT01775475 ·Status: COMPLETED ·Phase: PHASE2
-
Yttrium Y 90 Ibritumomab Tiuxetan, Etoposide, Cyclophosphamide, and an AHSCT in Non-Hodgkin's Lymphoma Patients
NCT00562978 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Aprepitant's Effect on Drug Metabolism in Multi-Day Combination (CHOP/R-CHOP) Chemotherapy Regimen in Lymphoma Patients
NCT00651755 ·Status: COMPLETED ·Phase: NA
-
Oral Combination Chemotherapy in Treating Elderly Patients With Intermediate or High-Grade Non-Hodgkin's Lymphomas
NCT00003113 ·Status: TERMINATED ·Phase: PHASE2
-
Linperlisib Combined With Chidamide in Patients With PTCL
NCT06421948 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Combination Chemotherapy in Treating Patients With Non-Hodgkin's Lymphoma or Acute Lymphocytic Leukemia
NCT00005977 ·Status: COMPLETED ·Phase: PHASE3
-
Zanubrutinib and G-CHOP in Untreated Intermediate-high Risk Follicular Lymphoma
NCT06474481 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Study of Escalating Doses of Romidepsin in Association With CHOP in the Treatment of Peripheral T-Cell Lymphomas
NCT01280526 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
CHOEP + High Dose Therapy + Auto SCT for T-Cell Lymphoma
NCT01746173 ·Status: TERMINATED ·Phase: PHASE2
-
Study to Assess the Effectiveness of RCHOP With or Without VELCADE in Previously Untreated Non-Germinal Center B-Cell-like Diffuse Large B-Cell Lymphoma Patients
NCT00931918 ·Status: COMPLETED ·Phase: PHASE2
-
Nivolumab and Combination Chemotherapy in Treating Participants With Diffuse Large B-Cell Lymphoma
NCT03704714 ·Status: SUSPENDED ·Phase: PHASE1/PHASE2