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Paclitaxel, Carboplatin and Radiotherapy as Induction Therapy in Locally Advanced Head and Neck Cancer

NCT00176254 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2023-05-16

Study results available
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Summary

This study utilizes two cycles of Paclitaxel and Carboplatin chemotherapies followed by four small doses of radiation, prior to other treatment (surgery or radiation). This study is evaluating if radiation as a chemoenhancer increases the response rate of initial therapy.

Conditions

Interventions

RADIATION

Radiotherapy

80 centigray (cGy) on Day 1 \& 2 and 22 \& 23 of chemotherapy

DRUG

Paclitaxel

225 mg/m2 intravenously over three hours on Days 1 and 22

DRUG

Carboplatin

Area under the curve (AUC) of 6 will be given intravenously over 30 minutes on days 1 and 22

Sponsors & Collaborators

Principal Investigators

  • Susanne Arnold, MD · University of Kentucky

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2000-05-31
Primary Completion
2012-10-31
Completion
2012-10-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00176254 on ClinicalTrials.gov