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Microvascular Response in Diabetes Mellitus

NCT00160927 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2007-03-19

No results posted yet for this study

Summary

Vascular and neurological mechanisms are both likely to be involved in foot ulcer. We recently reported on the hand an original transient pressure-induced vasodilation (PIV) during a 5 mmHg/min increase of pressure strain using laser Doppler flowmetry. This physiological response to non noxious external local pressure strain is a widely protective cutaneous mechanism. The impairment of PIV in diabetic subjects may be relevant to the high prevalence of foot ulcer that occurs in these individuals. The aim of the project is to analyse the different physiopathological processes involved in PIV impairment in diabetic subjects as compared to matched controls.

Conditions

Interventions

DEVICE

local heating

DEVICE

iontophoresis

DRUG

actylcholine

DRUG

sodium nitroprusside

Sponsors & Collaborators

  • Alfediam

    collaborator OTHER

  • UNIVALOIRE

    collaborator UNKNOWN

  • University Hospital, Angers

    lead OTHER_GOV

Principal Investigators

  • Jean Louis Saumet, MD PhD · Centre Hospitalier Universitaire Angers

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2003-01-31
Completion
2008-01-31

Countries

  • France

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00160927 on ClinicalTrials.gov