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A Prospective Study of Endothelial Dysfunction and Diabetic Foot Ulcer Risk

NCT00013286 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 750

Last updated 2009-01-21

No results posted yet for this study

Summary

This project will identify risk factors for diabetic foot ulcer by studying the relationship between endothelial dysfunction and foot ulcer risk. A fundamental defect in type 1 and 2 diabetic subjects is impaired vasodilatory reserve which is reflected in the dysfunction of endothelium-dependent vasodilation. Findings thus far point to an important role of the microvasculature in the development of diabetic foot ulcer and amputation.

In this study a a well-characterized cohort of 750 diabetic veterans without foot ulcer will be followed over 3-years.

Conditions

  • Diabetic Foot Ulcers

Interventions

DEVICE

Prevention Diabetic Foot Ulcer

Sponsors & Collaborators

Principal Investigators

  • John Fryer, Ph.D. Asst. Director · Program Analysis and Review Section (PARS), Rehabilitation Research & Development Service

  • Wijegupta Ellepola, Program Analyst · Program Analysis & Review Section (PARS), Rehabilitation Research & Development Service

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
1999-10-31
Completion
2002-09-30

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00013286 on ClinicalTrials.gov