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Positronic Emission Tomography (PET) Imaging in Post Radiation Evaluation of Head and Neck Tumours (PET PREVENT Trial)

NCT00147472 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 400

Last updated 2012-06-22

No results posted yet for this study

Summary

The purpose of this trial is to determine the ability of positron emission tomography (PET) to detect residual cancer in neck lymph nodes of patients following curative treatment with radiation therapy for squamous cell cancer arising in the head and neck.

Patients with head and neck cancer (HNC) undergo treatment of curative intent; patients who are node positive (N2 N3 stages) undergo standard management which includes post-radiation planned neck dissection but two thirds of patients end up not having evidence of residual disease in neck dissection specimens; these patients could have avoided surgery. However, currently used standard tests, like computed tomography (CT) and/or magnetic resonance imaging (MRI) cannot reliably predict who is post-radiation disease free.

Conditions

  • Cancer of the Head and Neck

Interventions

OTHER

PET scan in addition to conventional CT imaging

PET scans, Pre and post radiation treatment

Sponsors & Collaborators

  • Ontario Ministry of Health and Long Term Care

    collaborator OTHER_GOV

  • Ontario Clinical Oncology Group (OCOG)

    lead OTHER

Principal Investigators

  • John Waldron, MD · Princess Margaret Hospital, Canada

  • Ralph Gilbert, MD · Princess Margaret Hospital, Canada

  • Libni Eapen, MD · Ottawa Regional Cancer Centre

  • Anne Keller, MD · Princess Margaret Hospital, Canada

  • Mark N Levine, MD · Ontario Clinical Oncology Group (OCOG)

  • Bayardo Perez-Ordonez, MD · Princess Margaret Hospital, Canada

  • Chu-Shu Gu, M.Sc. · Ontario Clinical Oncology Group (OCOG)

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-05-31
Primary Completion
2009-08-31
Completion
2011-05-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00147472 on ClinicalTrials.gov