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The EMINENCE Study - PET/MR Imaging of Head Neck Cancer

NCT04612075 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 390

Last updated 2026-04-14

No results posted yet for this study

Summary

Head and neck cancers (HNC) often receive radiotherapy as part of their treatment. However, unacceptable failure rates and severe side effects remain a challenge. The improvements in radiotherapy are closely related to improvements in medical imaging. Functional imaging, where intratumoural characteristics such as tumour oxygenation, metabolism, and blood vessel function can be quantified, offers possibilities to personalize the radiotherapy. In this study we will establish the clinical workflow for PET- and MRI-based radiotherapy in HNC by acquiring images prior to and during radiotherapy to develop new concepts for image-based biologically adaptive radiotherapy, both based on photon-based radiotherapy and also proton therapy, which soon will be available for cancer patients in Norway. The investigators aim to contribute towards further developments of personalised high-precision radiotherapy for HNC patients resulting in improved outcome, reduced side-effects and better quality of life.

Conditions

  • Head and Neck Neoplasms

Interventions

DIAGNOSTIC_TEST

FDG-PET/MRI

Performed at baseline, interim and at 12-16 weeks post radiotherapy.

Sponsors & Collaborators

  • St. Olavs Hospital

    collaborator OTHER

  • University Hospital of North Norway

    collaborator OTHER

  • University of Bergen

    collaborator OTHER

  • Norwegian University of Science and Technology

    lead OTHER

Principal Investigators

  • Torstein Baade Rø, md phd · Norwegian University of Science and Technology, IKOM

  • Arne Solberg, md phd · St Olavs Hospital, Dept Oncology

  • Erik Wahlström, phd · Norwegian University of Science and Technology, Institute for Fysikk

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-01-12
Primary Completion
2025-12-31
Completion
2028-12-31

Countries

  • Norway

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04612075 on ClinicalTrials.gov