MedTrace Logo

Diuretics In the Management of Essential Hypertension (DIME) Study

NCT00131846 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 1130

Last updated 2024-06-14

No results posted yet for this study

Summary

The purpose of DIME is to evaluate the safety (i.e. new onset of diabetes and other metabolic adverse events), efficacy and cost-effectiveness of antihypertensive treatment with low dose diuretics. The researchers' hypothesis is that use of low dose thiazide diuretics is metabolically safe when used with other appropriate antihypertensives, effective in reduction of blood pressure and cheaper than treatment without diuretics. Therefore, this study is an equivalence trial.

Conditions

Interventions

DRUG

Thiazide diuretics

Any dosage, frequency, and duration

DRUG

No diuretics

Any antihypertensive regimen other than diuretics

Sponsors & Collaborators

  • University of the Ryukyus

    collaborator OTHER

  • Kyoto University

    lead OTHER

Principal Investigators

  • Shinichiro Ueda, MB, ChB, PhD · Department of Clinical Pharmacology & Therapeutics, University of the Ryukyus

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
79 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2004-04-30
Primary Completion
2012-08-31
Completion
2013-11-30

Countries

  • Japan

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00131846 on ClinicalTrials.gov