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TRENDY Follow-up: Study on Endothelial Function in Subjects With Type 2 Diabetes Mellitus

NCT00905528 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 69

Last updated 2015-03-25

No results posted yet for this study

Summary

Basal nitric oxide (NO) activity plays a pivotal role in the regulation of glomerular hemodynamics, and in animal experiments its alteration has been associated with morphological changes characteristic of diabetic nephropathy. The investigators aimed to assess in a prospective study: 1. basal NO activity of renal vasculature and 2. renal hemodynamics to examine whether impairment of basal NO activity of the renal vasculature is related to development and progression of diabetic nephropathy and other cardiovascular endpoints.

Conditions

Interventions

DRUG

Telmisartan 80 mg/d

DRUG

Ramipril 10 mg/d

Sponsors & Collaborators

  • University of Erlangen-Nürnberg Medical School

    lead OTHER

Principal Investigators

  • Roland E Schmieder, Prof. · Clinical Research Center, Department of Nephrology and Hypertension, University of Erlangen-Nuremberg

Eligibility

Min Age
30 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2002-01-31
Primary Completion
2004-12-31
Completion
2004-12-31

Countries

  • Germany

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00905528 on ClinicalTrials.gov