Comparison of Chemotherapy Regimens in Treating Children With Relapsed or Progressive Rhabdomyosarcoma
NCT00025363 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 150
Last updated 2013-01-17
Summary
Randomized phase II trial to compare the effectiveness of different combination chemotherapy regimens in treating children who have rhabdomyosarcoma. Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells
Conditions
- Alveolar Childhood Rhabdomyosarcoma
- Embryonal Childhood Rhabdomyosarcoma
- Embryonal-botryoid Childhood Rhabdomyosarcoma
- Previously Treated Childhood Rhabdomyosarcoma
- Recurrent Childhood Rhabdomyosarcoma
Interventions
- DRUG
-
vincristine sulfate
Given IV
- DRUG
-
irinotecan hydrochloride
Given IV
- DRUG
-
Given IV
- DRUG
-
doxorubicin hydrochloride
Given IV
- DRUG
-
ifosfamide
Given IV
- DRUG
-
etoposide
Given IV
- DRUG
-
tirapazamine
Given IV
- BIOLOGICAL
-
Given SC
- BIOLOGICAL
-
sargramostim
Given SC
- OTHER
-
pharmacological study
Correlative studies
- OTHER
-
pharmacogenomic studies
Correlative studies
- OTHER
-
laboratory biomarker analysis
Correlative studies
Sponsors & Collaborators
-
National Cancer Institute (NCI)
lead NIH
Principal Investigators
-
Philip Breitfeld · Children's Oncology Group
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Max Age
- 20 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2001-11-30
- Primary Completion
- 2007-10-31
Countries
- United States
Study Locations
More Related Trials
-
Vincristine, Dactinomycin, and Cyclophosphamide With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Low-Risk Rhabdomyosarcoma
NCT00075582 ·Status: COMPLETED ·Phase: PHASE3
-
Temsirolimus, Irinotecan Hydrochloride, and Temozolomide in Treating Younger Patients With Relapsed or Refractory Solid Tumors
NCT01141244 ·Status: COMPLETED ·Phase: PHASE1
-
Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk Neuroblastoma
NCT00567567 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors
NCT00025441 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Neuroblastoma
NCT00017368 ·Status: COMPLETED ·Phase: PHASE2
-
Irinotecan in Treating Children With Refractory Solid Tumors
NCT00004078 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy in Treating Patients With Previously Untreated Rhabdomyosarcoma
NCT00003958 ·Status: COMPLETED ·Phase: PHASE3
-
High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma
NCT00354744 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Compare Early Use of Vinorelbine and Maintenance Therapy for Patients With High Risk Rhabdomyosarcoma
NCT04994132 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed Neuroblastoma
NCT01767194 ·Status: COMPLETED ·Phase: PHASE2
-
Irinotecan and Temozolomide in Treating Young Patients With Recurrent Neuroblastoma
NCT00311584 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy in Treating Children With Solid Tumors That Have Not Responded to Previous Therapy
NCT00006095 ·Status: COMPLETED ·Phase: PHASE1
-
Irinotecan and Temozolomide in Combination With Existing High Dose Alkylator Based Chemotherapy for Treatment of Patients With Newly Diagnosed Ewing Sarcoma
NCT01864109 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Vinorelbine Tartrate and Cyclophosphamide in Combination With Bevacizumab or Temsirolimus in Treating Patients With Recurrent or Refractory Rhabdomyosarcoma
NCT01222715 ·Status: COMPLETED ·Phase: PHASE2
-
Tirapazamine Plus Cyclophosphamide in Treating Children With Refractory Solid Tumors
NCT00003288 ·Status: COMPLETED ·Phase: PHASE1
-
Carboplatin and Irinotecan in Treating Children With Refractory Solid Tumors
NCT00024284 ·Status: COMPLETED ·Phase: PHASE1
-
Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors
NCT01076530 ·Status: COMPLETED ·Phase: PHASE1
-
Intensive Chemo-Radiotherapy With Peripheral Blood Progenitor Cell Rescue for Children With Advanced Neuroblastoma and Sarcomas
NCT00165139 ·Status: COMPLETED ·Phase: PHASE2
-
Therapy Based on Stage of Disease and Risk Assessment in Treating Children With Neuroblastoma
NCT00002802 ·Status: COMPLETED ·Phase: PHASE3
-
Combination Chemotherapy in Treating Young Patients With Nonmetastatic Rhabdomyosarcoma
NCT00379457 ·Status: UNKNOWN ·Phase: PHASE3
-
Temozolomide and O6-benzylguanine in Treating Children With Solid Tumors
NCT00020150 ·Status: COMPLETED ·Phase: PHASE1
-
Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Neuroblastoma
NCT00004188 ·Status: COMPLETED ·Phase: PHASE3
-
High-Dose 131I-MIBG Therapy Combined With Vincristine and Five Days of Irinotecan for Resistant/Relapsed Neuroblastoma
NCT01313936 ·Status: COMPLETED ·Phase: PHASE1
-
Irinotecan in Treating Children With Refractory or Progressive Solid Tumors
NCT00016861 ·Status: COMPLETED ·Phase: PHASE1
-
Combination Chemotherapy in Treating Patients With Newly Diagnosed Metastatic Ewing's Sarcoma or Primitive Neuroectodermal Tumor
NCT00002643 ·Status: COMPLETED ·Phase: PHASE2