Gefitinib and Combination Chemotherapy in Treating Patients With Advanced Solid Tumors or Colorectal Cancer
NCT00025142 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL
Last updated 2013-05-15
Summary
RATIONALE: Biological therapies such as gefitinib may interfere with the growth of tumor cells and slow the growth of the tumor. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug with gefitinib may kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of gefitinib and oxaliplatin combined with leucovorin and fluorouracil in treating patients who have advanced solid tumors or colorectal cancer.
Conditions
Interventions
- DRUG
-
FOLFOX regimen
- DRUG
- DRUG
-
gefitinib
- DRUG
-
leucovorin calcium
- DRUG
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH - lead OTHER
Principal Investigators
-
Branimir I. Sikic, MD · Stanford University
Study Design
- Purpose
- TREATMENT
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2001-07-31
- Completion
- 2006-11-30
Countries
- United States
Study Locations
More Related Trials
-
Safety, Tolerability and Efficacy of ZD6126 in Combination With Oxaliplatin, 5-Fluorouracil and Leucovorin in Subjects With Metastatic Colorectal Cancer.
NCT00065117 ·Status: TERMINATED ·Phase: PHASE2
-
Combination Chemotherapy Plus Trastuzumab in Treating Patients With Advanced, Recurrent, or Metastatic Colorectal Cancer
NCT00006015 ·Status: TERMINATED ·Phase: PHASE2
-
Combination Chemotherapy With or Without SU5416 in Treating Patients With Metastatic Colorectal Cancer
NCT00021281 ·Status: UNKNOWN ·Phase: PHASE3
-
A Phase II Study of 5-Fluorouracil Administered as a One Hour Infusion in Combination With Calcium Leucovorin and Interferon Alpha-2A in Advanced Colorectal Cancer
NCT00001428 ·Status: COMPLETED ·Phase: PHASE2
-
Combination Chemotherapy in Treating Patients With Recurrent, Refractory, or Metastatic Solid Tumors or Lymphomas
NCT00019513 ·Status: COMPLETED ·Phase: PHASE1
-
Combination Chemotherapy in Treating Patients With Recurrent Metastatic Colorectal Cancer
NCT00003260 ·Status: UNKNOWN ·Phase: PHASE3
-
A Genotype-guided Study of Irinotecan Administered in Combination With 5-fluorouracil/Leucovorin (FOLFIRI) and Bevacizumab in Advanced Colorectal Cancer Patients
NCT01183494 ·Status: COMPLETED ·Phase: PHASE1
-
Combination Chemotherapy With or Without Irinotecan in Treating Patients With Stage III Colon Cancer
NCT00005979 ·Status: COMPLETED ·Phase: PHASE3
-
Irinotecan, Fluorouracil, Leucovorin, and Oxaliplatin as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer
NCT00080951 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase II, Double Blind Study of 2 Doses of ZACTIMA™(ZD6474) in Combination With FOLFIRI vs FOLFIRI Alone for the Treatment of Colorectal Cancer in Patients
NCT00454116 ·Status: COMPLETED ·Phase: PHASE2
-
S9415 Chemotherapy in Patients With Stage II or III Colon Cancer That Has Been Surgically Removed
NCT00002593 ·Status: COMPLETED ·Phase: PHASE3
-
Phase I/II Trial GOFL in Advanced Pancreatic Adenocarcinoma
NCT00154791 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Comparison of Combination Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer
NCT00066274 ·Status: COMPLETED ·Phase: PHASE2
-
A Trial of NIS793 With FOLFIRINOX in Pancreatic Cancer
NCT05546411 ·Status: TERMINATED ·Phase: PHASE2
-
FOLFOX +/- Ziv-Aflibercept for Esophageal and Gastric Cancer
NCT01747551 ·Status: COMPLETED ·Phase: PHASE2
-
Comparison of Three Chemotherapy Regimens in Treating Patients With Metastatic Colorectal Cancer
NCT00008281 ·Status: UNKNOWN ·Phase: PHASE3
-
Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer
NCT00003001 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Study to Evaluate the Effects of Sorafenib if Combined With Chemotherapy (FOLFOX6 or FOLFIRI) in the Second-Line Treatment of Colorectal Cancer
NCT00889343 ·Status: TERMINATED ·Phase: PHASE2
-
Study to Assess the Efficacy and Safety of Treatment With FOLFIRI-aflibercept Compared to Initial Treatment With FOLFIRI-aflibercept (for 6 Cycles) Followed by Maintenance With 5FU-aflibercept, in an Elderly Population With mCRC After Failure of an Oxaliplatin-based Regimen
NCT03279289 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase II Study of 2 Doses of ZD6474 (Vandetanib) in Combination With FOLFOX vs FOLFOX Alone for the Treatment of Colorectal Cancer
NCT00500292 ·Status: COMPLETED ·Phase: PHASE2
-
Short-Infusion Ziv-aflibercept in Treating Patients With Metastatic Colorectal Cancer Receiving Combination Chemotherapy
NCT01941173 ·Status: WITHDRAWN ·Phase: NA
-
Combination Chemotherapy in Treating Patients With Resected Colon Cancer
NCT00378716 ·Status: COMPLETED ·Phase: PHASE3
-
Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation
NCT05610163 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Irinotecan or Fluorouracil Plus Leucovorin in Treating Patients With Previously Treated Metastatic Colorectal Cancer
NCT00016952 ·Status: COMPLETED ·Phase: PHASE2
-
Irinotecan Hydrochloride, Fluorouracil, and Leucovorin Calcium With or Without Zibotentan in Treating Patients With Metastatic Colorectal Cancer
NCT01205711 ·Status: COMPLETED ·Phase: PHASE2