Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Relapsed or Refractory Non-Small Cell Lung Cancer
NCT00006458 · Status: UNKNOWN · Phase: PHASE1 · Type: INTERVENTIONAL
Last updated 2009-03-03
Summary
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
PURPOSE: Phase I trial to study the effectiveness of radiolabeled monoclonal antibody therapy in treating patients who have relapsed or refractory non-small cell lung cancer.
Conditions
Interventions
- RADIATION
-
indium In 111 monoclonal antibody MN-14
- RADIATION
-
yttrium Y 90 monoclonal antibody MN-14
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
Garden State Cancer Center at the Center for Molecular Medicine and Immunology
lead OTHER
Principal Investigators
-
Jack D. Burton, MD · Garden State Cancer Center at the Center for Molecular Medicine and Immunology
Study Design
- Purpose
- TREATMENT
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2000-08-31
Countries
- United States
Study Locations
More Related Trials
-
Monoclonal Antibody Therapy in Treating Patients With Advanced Kidney Cancer
NCT00003102 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Monoclonal Antibody Therapy in Treating Patients With Advanced Solid Tumors
NCT00052403 ·Status: WITHDRAWN ·Phase: PHASE1
-
Monoclonal Antibody Therapy in Treating Patients With Refractory Advanced Solid Tumors or Lymphoma
NCT00049712 ·Status: COMPLETED ·Phase: PHASE1
-
Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors
NCT04119024 ·Status: RECRUITING ·Phase: PHASE1
-
Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors
NCT03645928 ·Status: TERMINATED ·Phase: PHASE2
-
Interleukin-2 Plus Monoclonal Antibody Therapy in Treating Patients With Solid Tumors
NCT00002994 ·Status: COMPLETED ·Phase: PHASE1
-
T Cell Receptor Immunotherapy for Patients With Metastatic Non-Small Cell Lung Cancer
NCT02133196 ·Status: RECRUITING ·Phase: PHASE2
-
Study of TRM-1(TRAIL-R1 Monoclonal Antibody) in Subjects With Relapsed or Refractory Non-Small Cell Lung Cancer (NSCLC)
NCT00092924 ·Status: COMPLETED ·Phase: PHASE2
-
A2-ESO-1 TCR-Engineered T Cells for Relapsed/Refractory Advanced or Metastatic NY-ESO-1 Overexpression Positive Triple Negative Breast Cancer
NCT05989828 ·Status: RECRUITING ·Phase: PHASE1
-
Nivolumab or Expectant Observation Following Ipilimumab, Nivolumab, and Surgery in Treating Patients With High Risk Localized, Locoregionally Advanced, or Recurrent Mucosal Melanoma
NCT03220009 ·Status: WITHDRAWN ·Phase: PHASE2
-
A Study Using Tumor-Reactive Autologous Tumor Infiltrating Lymphocytes (TIL) in Metastatic Melanomas
NCT02375984 ·Status: TERMINATED ·Phase: PHASE2
-
An Investigational Immuno-therapy Study of Experimental Medication BMS-986156, Given by Itself or in Combination With Nivolumab in Patients With Solid Cancers or Cancers That Have Spread.
NCT02598960 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Melanoma or Brain Tumors
NCT00002754 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors
NCT06014658 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Nivolumab in Treating Patients With Metastatic Adrenocortical Cancer
NCT02720484 ·Status: TERMINATED ·Phase: PHASE2
-
Using Nivolumab Alone or With Cabozantinib to Prevent Mucosal Melanoma Return After Surgery
NCT05111574 ·Status: RECRUITING ·Phase: PHASE2
-
Tocilizumab, Ipilimumab, and Nivolumab for the Treatment of Advanced Melanoma, Non-Small Cell Lung Cancer, or Urothelial Carcinoma
NCT04940299 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Monoclonal Antibody Therapy in Treating Patients With Stage III or Stage IV Melanoma
NCT00004184 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Study of CP-675,206 in Refractory Melanoma
NCT00254579 ·Status: COMPLETED ·Phase: PHASE2
-
Immunotherapy (Nivolumab and Ipilimumab) With and Without a Live Biotherapeutic Product (EXL01) for the Treatment of Metastatic Renal Cell Cancer
NCT07128680 ·Status: RECRUITING ·Phase: PHASE1
-
Monoclonal Antibody Therapy in Treating Patients With Ovarian Epithelial Cancer, Melanoma, Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Non-Small Cell Lung Cancer
NCT00039091 ·Status: TERMINATED ·Phase: PHASE1
-
Nivolumab With or Without Ipilimumab in Treating Younger Patients With Recurrent or Refractory Solid Tumors or Sarcomas
NCT02304458 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma, Hormone Receptor Positive HER2 Negative Metastatic Refractory Breast Cancer or Stage III-IV Non-Small Cell Lung Cancer
NCT05098210 ·Status: RECRUITING ·Phase: PHASE1
-
Radiation, Chemotherapy, Vaccine and Anti-MART-1 and Anti-gp100 Cells for Patients With Metastatic Melanoma
NCT00923195 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-MT) for Patients With Melanoma.
NCT00688090 ·Status: COMPLETED ·Phase: PHASE1