Monoclonal Antibody Therapy in Treating Patients With Advanced Solid Tumors
NCT00052403 · Status: WITHDRAWN · Phase: PHASE1 · Type: INTERVENTIONAL
Last updated 2014-01-16
Summary
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
PURPOSE: Phase I trial to study the effectiveness of monoclonal antibody therapy in treating patients who have advanced solid tumors.
Conditions
- Unspecified Adult Solid Tumor, Protocol Specific
Interventions
- DRUG
-
monoclonal antibody anti-anb3 integrin
- PROCEDURE
-
anti-cytokine therapy
- PROCEDURE
-
antiangiogenesis therapy
- PROCEDURE
-
antibody therapy
- PROCEDURE
-
biological response modifier therapy
- PROCEDURE
-
growth factor antagonist therapy
- PROCEDURE
-
monoclonal antibody therapy
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
Barbara Ann Karmanos Cancer Institute
lead OTHER
Principal Investigators
-
Patricia LoRusso, DO · Harper Hospital
Study Design
- Purpose
- TREATMENT
- Masking
- NONE
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2002-02-28
More Related Trials
-
Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic
NCT02721732 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
NM32-2668 in Adult Patients With Selected Advanced Solid Tumors
NCT06299163 ·Status: TERMINATED ·Phase: PHASE1
-
This is a Phase 1 Trial of ZM008, an Anti-LLT1 Antibody, Used as Single Agent Followed by Combination Treatment With Toripalimab in Patients With Advanced Solid Tumors
NCT06451497 ·Status: RECRUITING ·Phase: PHASE1
-
Pembrolizumab in Treating Participants With Metastatic, Recurrent or Locally Advanced Cancer and Genomic Instability
NCT03428802 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Monoclonal Antibody Therapy in Treating Patients With Prostate Cancer
NCT00024232 ·Status: COMPLETED ·Phase: PHASE2
-
Monoclonal Antibody and Vaccine Therapy in Treating Patients With Stage III or Stage IV Melanoma That Has Been Removed During Surgery
NCT00025181 ·Status: COMPLETED ·Phase: PHASE1
-
An Early Phase Trial of RPTR-1-201 in Advanced Solid Tumors
NCT07293754 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
A Study of Gene Edited Autologous Neoantigen Targeted TCR T Cells With or Without Anti-PD-1 in Patients With Solid Tumors
NCT03970382 ·Status: SUSPENDED ·Phase: PHASE1
-
First-in-human Study of CRB-601-01 to Treat Patients With Advanced Solid Tumor.
NCT06603844 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
QUILT-3.049: NANT Triple Negative Breast Cancer (TNBC) Vaccine: Combination Immunotherapy in Subjects With TNBC Who Have Progressed on or After Anthracycline-based Chemotherapy
NCT03175666 ·Status: WITHDRAWN ·Phase: PHASE1/PHASE2
-
Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Relapsed or Refractory Non-Small Cell Lung Cancer
NCT00006458 ·Status: UNKNOWN ·Phase: PHASE1
-
GSK1572932A Antigen-Specific Cancer Immunotherapeutic as Adjuvant Therapy in Patients With Non-Small Cell Lung Cancer
NCT00480025 ·Status: TERMINATED ·Phase: PHASE3
-
Interleukin-7 and Vaccine Therapy in Treating Patients With Metastatic Melanoma
NCT00091338 ·Status: COMPLETED ·Phase: PHASE1
-
Monoclonal Antibody Therapy in Treating Patients With Relapsed or Refractory Solid Tumors
NCT00005061 ·Status: COMPLETED ·Phase: PHASE1
-
Immunotherapy of Stage III/IV Melanoma Patients
NCT00112242 ·Status: COMPLETED ·Phase: PHASE1
-
One Trial of JCXH-211 Intratumoral Injection Combined With Anti-PD-1 Antibody in Patients With Malignant Solid Tumors
NCT06781125 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
A Safety Study Of A Monoclonal Antibody Against A5B1 Integrin In Solid Tumors
NCT00915278 ·Status: TERMINATED ·Phase: PHASE1
-
A Study of GC203 TIL in Advanced Malignant Solid Tumors
NCT06375187 ·Status: RECRUITING ·Phase: PHASE1
-
QUILT-3.067: NANT Triple Negative Breast Cancer (TNBC) Vaccine: Molecularly Informed Integrated Immunotherapy in Subjects With TNBC Who Have Progressed on or After Standard-of-care Therapy.
NCT03387085 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
Study of TST005 in Patients With Locally Advanced or Metastatic Solid Tumors
NCT04958434 ·Status: TERMINATED ·Phase: PHASE1
-
Study of IMC-1121B in Patients With Advanced Solid Tumors Not Responding To Standard Therapy
NCT00786383 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of MNRP1685A in Patients With Locally Advanced or Metastatic Solid Tumors
NCT00747734 ·Status: COMPLETED ·Phase: PHASE1
-
S0351, CNTO 328 in Treating Patients With Unresectable or Metastatic Kidney Cancer
NCT00311545 ·Status: WITHDRAWN ·Phase: PHASE2
-
Adoptive Cell Transfer of Autologous Tumor Infiltrating Lymphocytes and High-Dose Interleukin 2 in Select Solid Tumors
NCT03991741 ·Status: TERMINATED ·Phase: PHASE1
-
Study of INBRX-105 and INBRX-105 With Pembrolizumab in Patients With Solid Tumors Including Head and Neck Cancer
NCT03809624 ·Status: TERMINATED ·Phase: PHASE1