LMB-9 Immunotoxin in Treating Patients With Advanced Colon, Breast, Non-small Cell Lung, Bladder, Pancreatic, or Ovarian Cancer
NCT00005858 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 25
Last updated 2019-11-04
Summary
Phase I trial to study the effectiveness of LMB-9 immunotoxin in treating patients who have advanced colon, breast, non-small cell lung, bladder, pancreatic, or ovarian cancer. The LMB-9 immunotoxin can locate tumor cells and kill them without harming normal cells.
Conditions
Interventions
- BIOLOGICAL
-
LMB-9 immunotoxin
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
University of Maryland, Baltimore
lead OTHER
Principal Investigators
-
Judith E. Karp, MD · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2000-04-30
- Primary Completion
- 2003-12-31
- Completion
- 2003-12-31
Countries
- United States
Study Locations
More Related Trials
-
Mesothelin-Targeted Immunotoxin LMB-100 Alone or in Combination With Nab-Paclitaxel in People With Previously Treated Metastatic and/or Locally Advanced Pancreatic Ductal Adenocarcinoma and Mesothelin Expressing Solid Tumors
NCT02810418 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Wilm's Tumor 1 Protein Vaccine to Treat Cancers of the Blood
NCT00923910 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Nivolumab Alone or in Combination With Ipilimumab in Treating Patients With Advanced Uterine Leiomyosarcoma
NCT02428192 ·Status: COMPLETED ·Phase: PHASE2
-
Phase I Evaluation of Immunotoxin LMB-100 Administered by Normothermic, Intrapleural Perfusion Following Cytoreductive Surgery in Participants With Pleural Mesotheliomas, or Pleural Effusions From Cancers Expressing Mesothelin
NCT05375825 ·Status: WITHDRAWN ·Phase: PHASE1
-
LMB-7 Immunotoxin in Treating Patients With Leptomeningeal Metastases
NCT00003020 ·Status: COMPLETED ·Phase: PHASE1
-
INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors
NCT04580485 ·Status: COMPLETED ·Phase: PHASE1
-
Peptide Vaccinations to Treat Patients With Low-Risk Myeloid Cancers
NCT00488592 ·Status: COMPLETED ·Phase: PHASE2
-
Mesothelin-Targeted Immunotoxin LMB-100 in People With Malignant Mesothelioma
NCT02798536 ·Status: COMPLETED ·Phase: PHASE1
-
Vaccine Therapy in Treating Patients With Recurrent B-Cell Lymphoma
NCT00561756 ·Status: COMPLETED ·Phase: PHASE1
-
Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors
NCT06014658 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
NM32-2668 in Adult Patients With Selected Advanced Solid Tumors
NCT06299163 ·Status: TERMINATED ·Phase: PHASE1
-
Mesothelin-Targeted Immunotoxin LMB-100 in Combination With Tofacitinib in Persons With Previously Treated Pancreatic Adenocarcinoma, Cholangiocarcinoma and Other Mesothelin Expressing Solid Tumors
NCT04034238 ·Status: COMPLETED ·Phase: PHASE1
-
Vaccine Therapy in Treating Patients With Stage IIC-IV Melanoma
NCT00085189 ·Status: COMPLETED ·Phase: PHASE2
-
A Personal Cancer Vaccine (NEO-PV-01) w/ Nivolumab for Patients With Melanoma, Lung Cancer or Bladder Cancer
NCT02897765 ·Status: COMPLETED ·Phase: PHASE1
-
Immunotoxin Therapy in Treating Patients With Advanced Cancer
NCT00006981 ·Status: COMPLETED ·Phase: PHASE1
-
Personalized Immunotherapy in Adults With Advanced Cancers Immunotherapy in Adults With Advanced Cancers
NCT03568058 ·Status: COMPLETED ·Phase: PHASE1
-
UV1 Vaccine With Pembrolizumab for Patients With Unresectable or Metastatic Melanoma
NCT03538314 ·Status: COMPLETED ·Phase: PHASE1
-
Immunotoxin Therapy in Treating Patients With Advanced Solid Tumors
NCT00066651 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of EMB-09 in Participants With Advanced or Metastatic Solid Tumors.
NCT05263180 ·Status: RECRUITING ·Phase: PHASE1
-
A Trial of Y101D, a PD-L1/TGF-β Bispecific Antibody, in Patients With Metastatic or Locally Advanced Solid Tumors
NCT05028556 ·Status: COMPLETED ·Phase: PHASE1
-
Lorvotuzumab Mertansine in Treating Younger Patients With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor, or Synovial Sarcoma
NCT02452554 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Autologous Tumor Infiltrating Lymphocytes in Patients With Solid Tumors
NCT03645928 ·Status: TERMINATED ·Phase: PHASE2
-
Tocilizumab, Ipilimumab, and Nivolumab for the Treatment of Advanced Melanoma, Non-Small Cell Lung Cancer, or Urothelial Carcinoma
NCT04940299 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Atezolizumab and CYT107 in Treating Participants With Locally Advanced, Inoperable, or Metastatic Urothelial Carcinoma
NCT03513952 ·Status: COMPLETED ·Phase: PHASE2
-
Phase II Trial of Allovectin-7® for Metastatic Melanoma
NCT00044356 ·Status: COMPLETED ·Phase: PHASE2