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Radiation Therapy With or Without Chemotherapy After Surgery in Treating Patients With Stage IB or Stage IIA Cervical Cancer

NCT00003209 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 700

Last updated 2012-07-11

No results posted yet for this study

Summary

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with radiation therapy may kill more tumor cells. It is not yet known whether giving radiation therapy with chemotherapy after surgery is more effective than radiation therapy alone after surgery in treating cervical cancer.

PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with or without chemotherapy after surgery in treating patients with stage IB or stage IIA cervical cancer.

Conditions

Interventions

BIOLOGICAL

bleomycin sulfate

DRUG

cisplatin

DRUG

fluorouracil

DRUG

ifosfamide

DRUG

methotrexate

DRUG

mitomycin C

DRUG

vinblastine sulfate

DRUG

vindesine

RADIATION

radiation therapy

Sponsors & Collaborators

  • Medical Research Council

    collaborator OTHER_GOV

  • European Organisation for Research and Treatment of Cancer - EORTC

    lead NETWORK

Principal Investigators

  • Jan B. Vermorken, MD, PhD · University Hospital, Antwerp

  • R. Paul Symonds, MD, FRCP, FRCR · University of Glasgow

Study Design

Purpose
TREATMENT

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
1997-12-31
Primary Completion
1999-12-31

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Drugs
Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00003209 on ClinicalTrials.gov