Combination Chemotherapy in Treating Patients With Liver Metastases From Colorectal Cancer

NCT00002716 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 135

Last updated 2016-07-13

No results posted yet for this study

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which chemotherapy regimen is more effective for metastatic colorectal cancer.

PURPOSE: Randomized phase III trial to compare the effectiveness of intrahepatic floxuridine, leucovorin, and dexamethasone with that of systemic fluorouracil and leucovorin in treating patients who have unresectable liver metastases from colorectal cancer.

Conditions

Interventions

DRUG: dexamethasone
DRUG: floxuridine
DRUG: fluorouracil
DRUG: leucovorin calcium
PROCEDURE: laparotomy
PROCEDURE: conventional surgery

Sponsors & Collaborators

National Cancer Institute (NCI)
collaborator NIH
Alliance for Clinical Trials in Oncology
lead OTHER

Principal Investigators

Nancy E. Kemeny, MD · Memorial Sloan Kettering Cancer Center

Study Design

Allocation: RANDOMIZED
Purpose: TREATMENT
Masking: NONE
Model: PARALLEL

Eligibility

Min Age: 18 Years
Sex: ALL
Healthy Volunteers: No

Timeline & Regulatory

Start: 1996-01-31
Primary Completion: 2006-03-31
Completion: 2006-08-31

Countries

United States
Australia
Peru
Puerto Rico

Study Locations

More Related Trials

Entities

Drugs

Diseases