A Comparison of Dapsone and Trimethoprim-Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
NCT00002283 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL
Last updated 2005-06-24
Summary
Evaluate the effectiveness rate of dapsone plus trimethoprim as a therapy for the first episode of Pneumocystis carinii pneumonia (PCP) in AIDS patients. Compare the rates and severity of adverse effects using dapsone versus trimethoprim - sulfamethoxazole (TMP / PurposeX). Establish relative toxicities with regard to suitability for outpatient treatment.
Conditions
- Pneumonia, Pneumocystis Carinii
- HIV Infections
Interventions
- DRUG
-
Trimethoprim
- DRUG
-
Sulfamethoxazole
- DRUG
-
Dapsone
Sponsors & Collaborators
-
Jacobus Pharmaceutical
lead INDUSTRY
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
Countries
- United States
Study Locations
More Related Trials
-
A Randomized, Comparative, Prospective Study of Daily Trimethoprim / Sulfamethoxazole (TMS) and Thrice-Weekly TMS for Prophylaxis Against PCP in HIV-Infected Patients
NCT00000748 ·Status: COMPLETED ·Phase: PHASE3
-
Gradual Initiation of Sulfamethoxazole/Trimethoprim as Primary Pneumocystis Carinii Pneumonia Prophylaxis
NCT00000816 ·Status: COMPLETED ·Phase: PHASE4
-
DB289 Versus TMP-SMX for the Treatment of Acute Pneumocystis Jiroveci Pneumonia (PCP)
NCT00302341 ·Status: TERMINATED ·Phase: PHASE3
-
A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral / Oral Trimethoprim - Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia in AIDS
NCT00002056 ·Status: COMPLETED ·Phase: NA
-
A Controlled Trial Comparing the Efficacy of Aerosolized Pentamidine and Parenteral/Oral Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia in AIDS
NCT00000715 ·Status: COMPLETED ·Phase: PHASE3
-
Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
NCT00001013 ·Status: COMPLETED ·Phase: PHASE3
-
Low Dose Trimethoprim-Sulfamethoxazole for the Treatment of Pneumocystis Jirovecii Pneumonia
NCT04851015 ·Status: RECRUITING ·Phase: PHASE3
-
Comparison of Two Dosage Regimens of Oral Dapsone for Prophylaxis of Pneumocystis Carinii Pneumonia in Pediatric HIV Infection
NCT00000739 ·Status: COMPLETED ·Phase: PHASE1
-
Comparison of Three Treatments for Pneumocystis Pneumonia in AIDS Patients
NCT00000730 ·Status: TERMINATED ·Phase: PHASE3
-
A Randomized, Double-Blind, Placebo Controlled Study of l-Leucovorin in Combination With Trimethoprim / Sulfamethoxazole in the Therapy of Pneumocystis Carinii Pneumonia in Patients With the Acquired Immunodeficiency Syndrome
NCT00002002 ·Status: COMPLETED ·Phase: NA
-
A Controlled Comparative Trial of Sulfamethoxazole-Trimethoprim Versus Aerosolized Pentamidine for Secondary Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients Receiving Azidothymidine (AZT)
NCT00000727 ·Status: COMPLETED ·Phase: PHASE3
-
Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
NCT00001014 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Two Forms of Pentamidine in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
NCT00002292 ·Status: COMPLETED ·Phase: NA
-
A Double-Blind Placebo-Controlled Group Comparative Study To Evaluate the Safety and Effectiveness of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in Patients With AIDS Post First Episode PCP
NCT00002053 ·Status: COMPLETED ·Phase: NA
-
A Phase II Open Randomized Comparison of 566C80 and Pentamidine Isethionate for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients Who Are Intolerant of Trimethoprim / Sulfamethoxazole
NCT00001996 ·Status: COMPLETED ·Phase: PHASE2
-
A Randomized, Double-Blind Study of 566C80 Versus Septra (Sulfamethoxazole/Trimethoprim) for the Treatment of Pneumocystis Carinii Pneumonia in AIDS Patients
NCT00000655 ·Status: COMPLETED ·Phase: PHASE2
-
The Safety and Effectiveness of Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Who Have Had PCP Before
NCT00002291 ·Status: COMPLETED ·Phase: NA
-
Trimethoprim/Sulfamethoxazole Combined With Caspofungin as First-line Therapy in PCP
NCT03978559 ·Status: UNKNOWN ·Phase: PHASE4
-
A Comparison of Atovaquone and Pentamidine in the Prevention of Pneumocystis Carinii Pneumonia in HIV-Infected Patients Who Cannot Take TMP/SMX
NCT00002340 ·Status: COMPLETED ·Phase: PHASE3
-
A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate With Leucovorin Protection for Patients With Pneumocystis Carinii Pneumonia.
NCT00002102 ·Status: COMPLETED ·Phase: NA
-
Study of Trimethoprim/Sulfamethoxazole as PCP Prophylaxis in CTD Patients
NCT01747278 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
An Open Label Study to Evaluate the Long-Term Safety and Effectiveness of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients
NCT00002030 ·Status: COMPLETED ·Phase: NA
-
A Double-Blind Group Comparative Study To Evaluate the Long-Term Safety and Effectiveness of Two Different Doses of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients With Multiple Episodes of PCP
NCT00002055 ·Status: COMPLETED ·Phase: NA
-
Aerosols in the Treatment of Pneumocystis Pneumonia: A Pilot Study Quantitating the Deposition of Aerosolized Pentamidine as Delivered in ACTG 040 and Comparing Its Toxicity With Parenteral Pentamidine Therapy
NCT00000722 ·Status: COMPLETED ·Phase: NA
-
A Double-Blind Study To Evaluate the Long-Term Safety and Effectiveness of 60 mg Versus 120 mg of Aerosol Pentamidine in the Prophylaxis of Pneumocystis Carinii Pneumonia in AIDS Patients
NCT00002054 ·Status: COMPLETED ·Phase: NA