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Women's Ischemia Syndrome Evaluation (WISE)

NCT00000554 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL

Last updated 2014-04-04

No results posted yet for this study

Summary

To evaluate innovative diagnostic methods that will improve the diagnostic reliability of cardiovascular testing in evaluation of ischemic heart disease in women. Innovative approaches proposed include physiologic or functional measurements such as impaired metabolism, perfusion, or endothelial function as well as assessment of epicardial coronary arteries by angiography. Other objectives include developing safe, accurate, and cost effective diagnostic approaches for evaluating women with suspected ischemic heart disease, and determining the frequency of myocardial ischemia in the absence of significant epicardial coronary stenosis, as well as the frequency of non-ischemic or non-cardiac chest pain. A key aspect of the WISE study is to determine whether evidence of myocardial ischemia occurs in the absence of obstructive coronary disease.

Conditions

Interventions

PROCEDURE

Angiography, MRI, Dobutamine-Stress Echocardiography, PET,

PROCEDURE

Myocardial Contrast Echo, Coronary Flow and Vasomotor Testing

Sponsors & Collaborators

  • National Heart, Lung, and Blood Institute (NHLBI)

    collaborator NIH

  • University of Pittsburgh

    lead OTHER

Principal Investigators

  • Sheryl Kelsey · University of Pittsburgh

  • Carl Pepine · University of Florida

  • Steven Reis · University of Pittsburgh

Study Design

Purpose
DIAGNOSTIC

Eligibility

Min Age
15 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2001-05-31
Primary Completion
2007-04-30
Completion
2007-04-30

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00000554 on ClinicalTrials.gov