Cardiac Arrhythmia Pilot Study (CAPS)

Summary

To compare the effectiveness of various drugs and drug combinations in suppressing complex ventricular arrhythmias, and to evaluate their safety.

Conditions

• Arrhythmia
• Cardiovascular Diseases
• Heart Diseases
• Ventricular Arrhythmia

Interventions

DRUG

encainide

DRUG

moricizine

DRUG

flecainide

DRUG

imipramine

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI)

  lead NIH

Principal Investigators

• Toshio Akiyama · University of Rochester

• Allan Barker · Salt Lake Clinic Research Foundation

• J. Bigger · Columbia University

• Robert Capone · Rhode Island Hospital

• Lawrence Griffith · Johns Hopkins University

• Craig Pratt · Baylor College of Medicine

• David Richardson · Medical College of Virginia

• William Rogers · University of Alabama at Birmingham

• Michael Sather · V.A. Medical Center

• Israel Stein · Clinical Data, Inc

• Pierre Theroux · Montreal Heart Institute

• Raymond Woosley · Vanderbilt University Medical Center

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Eligibility

Min Age

18 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

1982-09-30

Completion

1985-09-30