Ablation vs Drug Therapy for Atrial Fibrillation - Pilot Trial
NCT00578617 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60
Last updated 2013-01-04
Summary
The CABANA pilot study is designed to test the hypothesis that the treatment strategy of percutaneous left atrial catheter ablation for the purpose of the elimination of atrial fibrillation (AF) is superior to current state-of-the-art therapy with either rate control or anti-arrhythmic drugs for reducing AF recurrences at 1 year follow-up.
Conditions
Interventions
- DRUG
-
Rate Control
Metoprolol 50-100mg
- DEVICE
-
Ablation Therapy
- DRUG
-
Rate Control
Atenolol 50-100mg,
- DRUG
-
Rate control
Propranolol 40-80mg
- DRUG
-
Rate control
Acebutolol 200mg
- DRUG
-
Rate control
Carvedilol 6.25mg
- DRUG
-
Rate Control
Diltiazem 180-240mg
- DRUG
-
Rate Control
Verapamil 180-240mg
- DRUG
-
Rate Control
Digoxin 0.125mg
- DRUG
-
Rhythm Control
Propafenone 450mg
- DRUG
-
Rhythm control
Flecainide 200mg
- DRUG
-
Rhythm control
Sotalol 240mg
- DRUG
-
Rhythm control
Dofetilide 500mcg
- DRUG
-
Rhythm control
Amiodarone 200mg
- DRUG
-
Rhythm control
Quinidine 600-900mg
Sponsors & Collaborators
-
Duke Clinical Research Institute
collaborator OTHER -
Abbott Medical Devices
collaborator INDUSTRY - lead OTHER
Principal Investigators
-
Douglas L. Packer, M.D. · Mayo Clinic
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 90 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2006-09-30
- Primary Completion
- 2009-02-28
- Completion
- 2010-06-30
Countries
- United States
Study Locations
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