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Nanoparticle gene editing restores CFTR function in cystic fibrosis lab model

Apr 25, 2026

Researchers developed a lipid nanoparticle gene-editing approach that inserted a full CFTR gene into airway cells and restored 88% to 100% of normal channel function in a cystic fibrosis lab model.

Lipid Nanoparticles Deliver Full CFTR Gene in Cystic Fibrosis Gene Therapy Advance

Feb 18, 2026

UCLA researchers developed lipid nanoparticle-based gene editing that inserts a complete CFTR gene into human airway cells, restoring up to 100% of normal channel function in cystic fibrosis laboratory models without viral vectors.