MIT engineers trained a language model on yeast codon usage to design genes that boost protein production, outperforming commercial tools for five of six proteins. The approach could lower drug development costs by improving yields of protein-based medicines.
Researchers developed a lipid nanoparticle gene-editing approach that inserted a full CFTR gene into airway cells and restored 88% to 100% of normal channel function in a cystic fibrosis lab model.
UCLA researchers developed lipid nanoparticle-based gene editing that inserts a complete CFTR gene into human airway cells, restoring up to 100% of normal channel function in cystic fibrosis laboratory models without viral vectors.
