NCT05845450 Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN) Status RECRUITING Phase PHASE2
NCT05744375 Trastuzumab Deruxtecan in First-line HER2-positive Locally Advanced/MBC Patients Resistant to Trastuzumab+Pertuzumab Status TERMINATED Phase PHASE2
NCT05704829 NeoAdjuvant Therapy With Trastuzumab-deruxtecan Versus Chemotherapy+Trastuzumab+Pertuzumab in HER2+ Early Breast Cancer Status RECRUITING Phase PHASE2
NCT05633979 Phase 1b Study of EZH1/2 Inhibitor Valemetostat in Combination With Trastuzumab Deruxtecan in Subjects With HER2 Low/Ultra-low/Null Metastatic Breast Cancer Status ACTIVE_NOT_RECRUITING Phase PHASE1
NCT05614739 FORAGER-1: A Study of Vepugratinib (LY3866288; LOXO-435) in Participants With Cancer With a Change in a Gene Called FGFR3 Status RECRUITING Phase PHASE1
NCT05594082 Real-world Effectiveness and Safety Study of T-Dxd in Chinese Metastatic Breast Cancer Status UNKNOWN Phase N/A
NCT05480384 Adjuvant Trastuzumab Deruxtecan (Enhertu) & Nivolumab For Patients Who Are Disease Free After Completion of Trimodality Treatment For HER-2+ Cancers of Esophagus & Gastroesophageal Junction Status ACTIVE_NOT_RECRUITING Phase PHASE2
NCT05458401 EUropean Real-world Experience Of Previously Treated Advanced/Metastatic HER2-positive Breast Cancer Patients Accessing Trastuzumab Deruxtecan Status COMPLETED Phase N/A
NCT05408845 Testing the Use of Ado-Trastuzumab Emtansine Compared to the Usual Treatment (Chemotherapy With Docetaxel Plus Trastuzumab) or Trastuzumab Deruxtecan for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancers Status RECRUITING Phase PHASE2
NCT05376878 An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis Status RECRUITING Phase PHASE4
NCT05372614 Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene Status RECRUITING Phase PHASE1
NCT05246514 A Single Arm Phase 2 Study to Evaluate Efficacy and Safety of Trastuzumab Deruxtecan for Patients With HER2 Mutant NSCLC Status ACTIVE_NOT_RECRUITING Phase PHASE2
NCT05113251 Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer Status ACTIVE_NOT_RECRUITING Phase PHASE3
NCT05091528 A Safety and Activity Study of SBT6050 in Combination With Other HER2-directed Therapies for HER2-positive Cancers Status TERMINATED Phase PHASE1/PHASE2
NCT05048797 A Study to Investigate the Efficacy and Safety of Trastuzumab Deruxtecan as the First Treatment Option for Unresectable, Locally Advanced/Metastatic Non-Small Cell Lung Cancer With HER2 Mutations Status ACTIVE_NOT_RECRUITING Phase PHASE3
NCT04989816 Study of T-DXd Monotherapy in Patients With HER2-expressing Locally Advanced or Metastatic Gastric or GEJ Adenocarcinoma Who Have Received 2 or More Prior Regimens Status COMPLETED Phase PHASE2
NCT04784715 Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09) Status ACTIVE_NOT_RECRUITING Phase PHASE3
NCT04752059 Phase II Study of T-DX in HER2-positive Breast Cancer Brain Metastases Status COMPLETED Phase PHASE2