Two phase 3 trials tested radiation approaches for brain metastases. Tile-based brachytherapy cut 1-year recurrence to 1.3% and improved median overall survival. Stereotactic radiation reduced symptom burden versus whole brain radiation.
Phase III trial of 196 patients shows stereotactic radiation targeting individual tumors significantly improved symptom burden and daily functioning compared with hippocampal-avoidance whole-brain radiation, without compromising survival.
Precision oncology has transformed brain metastases treatment from lung cancer, extending survival from 6-12 months to 3-5 years through targeted therapies, immunotherapy, and radiosurgery. With 100,000-200,000 annual cases in the US, multidisciplinary approaches now manage this once-terminal condition as a chronic disease.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07767981 |
Microbiome Determinants of Adverse Effects of Stereotactic Radiosurgery |
RECRUITING | |
| NCT07680127 |
TENS of Auricular Vagal Nerve for Radiation Necrosis |
NOT_YET_RECRUITING | NA |
| NCT07632092 |
Early [18F]-FDG PET Dynamic Analysis in Brain Metastases After Radiotherapy. |
RECRUITING | |
| NCT07422168 |
Hyperbaric Oxygen Therapy for Treatment of Severe Radiation-Induced Complications |
COMPLETED | NA |
| NCT06888817 |
Bevacizumab Versus Corticosteroids as First-line Treatment in Patients With Symptomatic Cerebral Radiation Necrosis After Radiation for High-grade Glioma or Brain Metastases |
RECRUITING | PHASE3 |
| NCT05762172 |
Dynamic F-DOPA PET for Differential Diagnosis Between Recurrence and Radionecrosis of Brain Metastasis |
COMPLETED | NA |
| NCT05124912 |
REMASTer: REcurrent Brain Metastases After SRS Trial |
RECRUITING | NA |
| NCT02819479 |
Low-dose Intra-arterial Bevacizumab for Edema and Radiation Necrosis Therapeutic Intervention (LIBERTI) |
COMPLETED | PHASE2 |
| NCT02212964 |
Differentiation of Pseudoprogression and True Progression Through High Field Susceptibility Weighted Imaging and R2* |
COMPLETED | |
| NCT01651078 |
Laser Ablation After Stereotactic Radiosurgery |
COMPLETED |
