Evidence on ketogenic diets remains limited for psychiatric disorders and diabetes, while a systematic review in overweight and obese women with PCOS found significant short-term improvements. Experts said more controlled, long-term studies are needed.
A meta-analysis of 68 studies found patients with mental disorders consistently showed higher brain age than healthy controls. The largest effects were seen in schizophrenia spectrum and neurocognitive disorders.
Studies of psilocybin found lasting shifts in life values in healthy volunteers and reduced fear of death in therapeutic settings. Trials have also reported benefits in cancer patients.
Lipocine's oral postpartum depression drug LPCN 1154 failed to meet its primary endpoint in a Phase 3 trial involving 90 patients. However, a post hoc analysis showed clinically meaningful improvements in a subset of 54 patients with psychiatric history, and the drug demonstrated a favorable safety profile supporting outpatient use.
A study of 1.9 million births in Sweden found new fathers have a 30% increased risk of depression and anxiety disorders by their baby's first birthday. The research highlights the need for better mental health screening and support for fathers during the postpartum period.
A longitudinal study of 460,000 teenagers found that adolescent cannabis use increases the risk of developing bipolar and psychotic disorders by twofold, as well as raising risks for depression and anxiety.