GSK's antibody-drug conjugate risvutatug rezetecan has received Orphan Drug Designation in Japan for small-cell lung cancer, marking its sixth global regulatory designation. The decision was based on phase I trial data showing durable responses in extensive-stage SCLC patients. The drug is currently in phase III development for relapsed ES-SCLC.
New research demonstrates that physical activity after cancer diagnosis reduces mortality risk in less common cancers and enhances circadian clock function in tumor tissue, supporting exercise as a therapeutic intervention.
Early trial of Rezatapopt shows 20% response rate in advanced cancers with p53 mutations, while researchers identify AMD3100 as potential solution to enable immunotherapy in rare liver cancer.
Study finds FDA-approved drug AMD3100 can mobilize immune T cells to attack fibrolamellar carcinoma, a rare liver cancer affecting children and young adults that has resisted immunotherapy treatment.
Researchers find that AMD3100, an existing FDA-approved drug, can reverse T-cell exclusion in fibrolamellar carcinoma, potentially allowing immunotherapy to fight the rare and fatal liver cancer that primarily affects children and young adults.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07424547 |
Phase I Study of SYS6043 in Patients With Advanced/Metastatic Solid Tumors |
RECRUITING | PHASE1 |
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ACTIVE_NOT_RECRUITING | NA |
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COMPLETED | NA |
| NCT07296510 |
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COMPLETED | |
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RECRUITING | PHASE2 |
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Lung Ultrasound Versus Inferior Vena Cava Collapsibility Index for Early Prediction of Volume Overload During Transurethral Resection of Prostate |
ENROLLING_BY_INVITATION | NA |
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Feasibility and Safety of a Single Working Element for Bipolar and Laser Enucleation in Prostate Surgery: A Prospective Study |
RECRUITING | |
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COMPLETED | NA |
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NOT_YET_RECRUITING | NA |
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NOT_YET_RECRUITING |
