News Related to Obesity

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Intermittent Fasting Not Superior for Weight Loss, Meta-Analysis Finds

Aug 22, 2026

A Cochrane meta-analysis of 22 studies with nearly 2,000 participants found intermittent fasting is not particularly effective for weight loss in obese or overweight adults and does not differ significantly from standard dietary advice. Experts note it remains an alternative at least as effective as classic calorie restriction, but more long-term trials are needed.

Post-Meal SPARC Level Predicts Mediterranean Diet Benefits

Aug 19, 2026

A study in Life Metabolism shows that a single post-meal blood biomarker, 1-hour postprandial SPARC, predicts who benefits most from a Mediterranean diet. Lower baseline SPARC-1H levels were linked to greater improvements in insulin resistance and glucose control in a six-month trial.

Obesity-Microbiome Axis Drives Immune Checkpoint Inhibitor Efficacy, New Research Shows

Jul 09, 2026

New research shows obesity-associated immune checkpoint inhibitor efficacy depends on the diet–gut microbiome axis rather than metabolic dysfunction. Human-to-mouse fecal microbiota transplants from high-BMI donors enhanced ICI efficacy, while a review outlines obesity-related inflammation's role in lung cancer immunotherapy outcomes and biomarkers.

Gut Microbiome Shapes Cancer Immunotherapy Outcomes Across New Studies

Aug 06, 2026

New research links gut microbiome composition to cancer immunotherapy outcomes. A 674-patient study showed gut bacteria predict melanoma recurrence with up to 94% accuracy, while other studies identified specific microbes influencing treatment response and resistance in melanoma and liver cancer.