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Toxin Exposure and Immune Dysregulation in Non-Hodgkin Lymphoma

NCT07652580 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2026-06-17

No results posted yet for this study

Summary

The goal of this observational cohort study is to learn how toxin and occupational exposures, germline genetic variation, and immune dysregulation relate to B-cell non-Hodgkin lymphoma among active-duty service members and other Military Health System beneficiaries. The main questions are whether specific exposures and germline variants are associated with B-cell NHL subtype, immune dysfunction, and clinical outcomes. Participants will complete exposure and medical-history surveys, provide biospecimens for immune and genomic testing, and may be followed annually for up to 3 years.

Conditions

Sponsors & Collaborators

  • Uniformed Services University of the Health Sciences

    collaborator FED

  • Murtha Cancer Center

    collaborator UNKNOWN

  • Walter Reed National Military Medical Center

    collaborator FED

  • United States Naval Medical Center, Portsmouth

    collaborator FED

  • Children's Hospital Medical Center, Cincinnati

    collaborator OTHER

  • The American Genome Center

    collaborator UNKNOWN

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

    lead OTHER

Principal Investigators

  • Christin Destefano · Uniformed Services University of the Health Sciences

Eligibility

Min Age
4 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-05-01
Primary Completion
2028-05-01
Completion
2028-05-01

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07652580 on ClinicalTrials.gov