Efficacy of AI-Driven and Traditional Physical Therapy Programs in Patients With Knee Osteoarthritis

Summary

This study aims to compare the effectiveness of an artificial intelligence (AI)-guided physical therapy program with a traditional physical therapy program in patients with knee osteoarthritis.

Forty patients with knee osteoarthritis will be randomly assigned to one of two groups. The traditional physical therapy group will receive a conventional rehabilitation program including transcutaneous electrical nerve stimulation (TENS), strengthening, flexibility, and balance exercises. The AI-guided group will receive an individualized rehabilitation program generated using ChatGPT-4 based on standardized patient information and clinical assessment findings.

Both groups will receive education regarding lifestyle modification and joint protection strategies. The effects of the two rehabilitation approaches will be evaluated by measuring pain intensity, knee range of motion, knee-related functional ability, and functional mobility and fall risk before and after the intervention.

The study will determine whether an AI-guided physical therapy program can provide outcomes comparable or superior to those of traditional physical therapy in individuals with knee osteoarthritis.

Conditions

• Knee Osteoarthritis

Interventions

OTHER

AI-Guided Physical Therapy Program

Participants will receive an individualized physical therapy program generated using ChatGPT-4. The researcher will manually enter standardized patient data, including age, sex, pain intensity (VAS), functional disability (WOMAC), knee range of motion, symptom duration, and physical activity level. ChatGPT-4 will be prompted to generate an evidence-based, in-clinic rehabilitation program for adults with knee osteoarthritis.

OTHER

Traditional Physical Therapy Program

Participants will receive a traditional physical therapy program including transcutaneous electrical nerve stimulation (TENS), strengthening exercises, flexibility exercises, and balance exercises. The intervention will be administered three sessions per week for 12 weeks.

BEHAVIORAL

Lifestyle Modification and Joint Protection Education

Participants in both study arms will receive education on lifestyle modification and joint protection strategies as part of the management of knee osteoarthritis.

Sponsors & Collaborators

• Cairo University

  lead OTHER

Principal Investigators

• Mohsen El Sayyed, PhD · Professor, Cairo University

• Rania Reda Mohamed, PhD · Assistant Professor, Cairo University

• Ali Al- Zawahri, PhD · Professor, Cairo University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

45 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-08-21

Primary Completion

2026-11-21

Completion

2026-11-30

Countries

• Egypt

Study Locations