Ependymoma is a primary central nervous system tumor arising from ependymal cells and can occur in the brain or spinal cord. It represents a biologically heterogeneous group of tumors with distinct molecular and anatomic subtypes. Management is centered on maximal safe resection and risk-adapted adjuvant therapy.
Southern RNA and Providence Therapeutics will support a clinical trial testing personalized mRNA cancer vaccines for children with treatment-resistant brain tumors, marking the first multi-site pediatric study of its kind.
Research shows TET2-driven clonal hematopoiesis improves immune checkpoint blockade efficacy in solid tumors, while separate studies identify new immune pathways in childhood brain cancers and mechanisms behind immunotherapy resistance.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07589361 |
Safety and Efficacy of Vertebral Body-Sparing Craniospinal Irradiation With Proton Therapy in Pediatric Tumors |
NOT_YET_RECRUITING | |
| NCT07424092 |
Intratumoral DNX-2401 for High Grade Pediatric Brain Tumors |
ACTIVE_NOT_RECRUITING | PHASE2 |
| NCT07390539 |
B7-H3.CD28Z.CART in CNS Neoplasms |
NOT_YET_RECRUITING | PHASE1 |
| NCT07061626 |
Determine Maximum Tolerated Dose, Safety, and Tolerability of Rhenium (186Re) in Pediatric Recurrent, Refractory or Progressive Ependymoma and High-Grade Glioma |
NOT_YET_RECRUITING | PHASE1 |
| NCT07031765 |
Peds CHAMP1ON - Hematopoietic Stem Cell And Monoclonal Antibody PD-1 Blockade for RecurreNt Pediatric High-Grade Glioma |
ACTIVE_NOT_RECRUITING | PHASE1 |
| NCT06804655 |
Pharmacoscopy for Patients With Refractory Primary Brain Tumors |
NOT_YET_RECRUITING | PHASE2 |
| NCT06779487 |
Systemic Biomarkers to Predict Radiation-Induced Neurocognitive Decline |
RECRUITING | |
| NCT06639607 |
PEP-CMV + Nivolumab for Newly Diagnosed Diffuse Midline Glioma/High-grade Glioma and Recurrent Diffuse Midline Glioma/High-grade Glioma, Medulloblastoma, and Ependymoma |
NOT_YET_RECRUITING | PHASE1/PHASE2 |
| NCT06521567 |
A Study of Cobolimab Plus Dostarlimab in Pediatric and Young Adult Participants With Cancer |
ACTIVE_NOT_RECRUITING | PHASE1/PHASE2 |
| NCT06499636 |
In Vitro Models From Pediatric Brain Tumors |
NOT_YET_RECRUITING |
