Chronic hepatitis B is a long-term liver infection caused by hepatitis B virus that can progress to cirrhosis and liver cancer. It is a major global health problem despite the availability of effective vaccination and antiviral management.
January and March 2026 drug pipeline updates included Phase 3 results, Fast Track designations and Priority Review decisions across multiple disease areas. Mavacamten, teplizumab-mzwv, anifrolumab, AXS-05, gedatolisib and AFTX-201 were among the programs with notable milestones.
GSK agreed to license linerixibat to Alfasigma in a deal worth up to $690 million, while Eisai received orphan drug designation in Japan for E2086, a novel selective orexin 2 receptor agonist for narcolepsy.
Precision BioSciences receives FDA Fast Track designation for PBGENE-DMD, a gene editing therapy for Duchenne muscular dystrophy designed to treat patients with mutations in exons 45-55.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07600788 |
A Clinical Study Evaluating the Pharmacokinetic Characteristics and Safety of AHB-137 Injection in Participants With Mild to Moderate Liver Dysfunction and Those With Normal Liver Function. |
NOT_YET_RECRUITING | PHASE1 |
| NCT07595159 |
A Study of BW-20507 in Chinese Healthy Subjects and Subjects With Chronic Hepatitis B |
COMPLETED | PHASE1 |
| NCT07589400 |
Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Characteristics of ACT500 in Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease Complicated With Chronic Hepatitis B |
NOT_YET_RECRUITING | PHASE1 |
| NCT07588009 |
Phase IIIB Extension Clinical Trial of Efficacy and Safety of GST-HG141 (Nairevir) Combined With NAs in Chronic Hepatitis B |
NOT_YET_RECRUITING | PHASE3 |
| NCT07573943 |
ASC22 Combined With Peg-IFNa in Achieving Functional Cure in Patients With Chronic Hepatitis B Virus Infection |
RECRUITING | PHASE4 |
| NCT07540637 |
Assessment of Treatment Adherence and Associated Factors in Chronic HepB Patients Supported by HBVCare |
RECRUITING | NA |
| NCT07537387 |
A Study on the Pursuit of Sustained Clearance of HBsAg in Chronic Hepatitis B(CHB) Patients With Previous Interferon Treatment Using Pegylated Interferon Alpha |
NOT_YET_RECRUITING | |
| NCT07520123 |
Union-FAST: An Intelligent-Agent Intervention to Increase Antiviral Treatment Uptake in Diagnosed-but-Untreated Hepatitis B Patients |
NOT_YET_RECRUITING | NA |
| NCT07449091 |
Adaptability of an Undetectable = Untransmissible Model for HBV |
RECRUITING | |
| NCT07345624 |
Entecavir With or Without Pegylated Interferon α-2b in Children Aged 3-6 Years With Immune-Tolerant Chronic Hepatitis B |
NOT_YET_RECRUITING | PHASE4 |
