Arrhythmias are irregular heart rhythms caused by abnormal electrical signaling in the heart. The heartbeat may be too fast, too slow, or irregular, and severity ranges from benign to life-threatening.
Scientists at Cincinnati Children's have identified a molecular pathway responsible for immune checkpoint inhibitor-induced myocarditis and demonstrated that blocking TNF signaling can prevent this fatal complication without compromising anti-tumor efficacy.
A redesigned CD40 agonist antibody achieved complete remission in two of 12 patients with metastatic cancer in early trials, while separate research identified a method to prevent deadly heart complications from immune checkpoint inhibitors.
T-cell immunotherapies including CAR T-cell therapy and T-cell engagers are expanding cancer treatment options but present significant cardiovascular risks and operational complexities requiring coordinated multidisciplinary management.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT07336225 |
CMR-Based Prognostic Study in Patients With Cardiac Implantable Electronic Devices |
RECRUITING | |
| NCT07260721 |
Evaluation of a Single-lead ECG Patch-based Telemetry System for In-hospital Monitoring |
NOT_YET_RECRUITING | NA |
| NCT06674278 |
Changes in Electrocardiographic (ECG) Ventricular Repolarization and Transthoracic Impedance Cardiography (ICG) Parameters in Patients with COVID-19 and After the Disease: Persistence and Prognostic Significance of These Changes |
NOT_YET_RECRUITING | |
| NCT06591923 |
a Foundational Model for Cardiovascular Disease Diagnosis and Prediction |
NOT_YET_RECRUITING | |
| NCT06039176 |
Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future |
RECRUITING | |
| NCT05994755 |
Association Between Cardiac ARRHYTHMIAs and Glycemic Variability in Patient With Type 2 Diabetes Monitored Through FREEstyle Libre and Bluetooth Technology. |
UNKNOWN | |
| NCT04563091 |
Potassium Kinetic During and After Hemodialysis and Potassium Profiling to Prevent Arrhythmias |
UNKNOWN | NA |
| NCT03289429 |
Antiarrhythmic and Cardioprotective Effects of Atorvastatin Versus Magnesium Sulfate in Cardiac Valve Replacement Surgery |
UNKNOWN | PHASE4 |
| NCT03121183 |
Medico-economic Evaluation of Strategies for the Lead Extraction of Implantable Defibrillator and Pacemakers |
UNKNOWN | |
| NCT03110146 |
EnSite Precision 2.1 Feasibility Study |
COMPLETED |
