Acid reflux (gastroesophageal reflux) occurs when stomach contents flow back into the esophagus and may cause heartburn. Gastroesophageal reflux disease (GERD) is the more severe, long-lasting form in which reflux causes bothersome recurrent symptoms or complications over time.
Bunnie Xo, wife of country star Jelly Roll, revealed she experienced suicidal thoughts while taking semaglutide, describing December 2025 as "one of the darkest times of my life." She emphasized the importance of discussing mental health side effects of weight-loss medications and encouraged others facing similar struggles to seek help.
Microdosing GLP-1 medications like Ozempic and Wegovy has emerged as a weight-loss trend, but health experts warn there is no scientific data supporting the practice and caution about potential safety risks.
| NCT ID | Title | Status | Phase |
|---|---|---|---|
| NCT06241183 |
Famotidine and Antacids for Treatment of Dyspepsia |
RECRUITING | PHASE4 |
| NCT04883567 |
The Use of AI to Improve Quality of OGD |
UNKNOWN | |
| NCT03516188 |
Efficacy of Gaviscon-Advance® in Suppressing Post-supper Acid-pocket and Night-time Acid-reflux in Obese Participants |
COMPLETED | PHASE2/PHASE3 |
| NCT02749071 |
An Investigation of the EndoStim® Lower Esophageal Sphincter (LES) Stimulation System for the Treatment of Reflux |
TERMINATED | NA |
| NCT02700087 |
In Infants With Laryngomalacia, Does Acid-Blocking Medication Improve Respiratory Symptoms? |
WITHDRAWN | NA |
| NCT02226484 |
Can Quercetin Increase Claudin-4 and Improve Esophageal Barrier Function in GERD? |
COMPLETED | PHASE1 |
| NCT01710995 |
A Three-Period Study to Investigate the Relative Bioavailability and Pharmacodynamic Profiles of a Zegerid 20mg Capsule, Zegerid 20mg Powder for Oral Suspension and Losec 20mg Capsule in Healthy Adult Volunteers Under Fasting Conditions |
COMPLETED | PHASE1 |
| NCT01705275 |
A Study to Investigate the Effect of ONO-8539 on Acid-Induced Oesophageal Hypersensitivity in Healthy Volunteers |
COMPLETED | PHASE1 |
