Clinical Trials

NCT06498635 | RECRUITING | PHASE3

306 participants

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2025-04-01

Completion:

2039-07-15

Conditions

• Lung Non-Small Cell Carcinoma
• Stage II Lung Cancer AJCC v8
• Stage IIIA Lung Cancer AJCC v8
• Stage IIIB Lung Cancer AJCC v8

Interventions

• PROCEDURE
• BIOLOGICAL
• OTHER

No Results Yet

NCT06497842 | COMPLETED | NA

14 participants

Effort During Resistance Training in Type 2 Diabetes

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-09-10

Completion:

2026-03-05

Conditions

• Type2 Diabetes Mellitus

Interventions

• BEHAVIORAL

No Results Yet

NCT06472908 | ACTIVE_NOT_RECRUITING | PHASE3

8862 participants

Efficacy and Safety of Colchicine After PCI

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-07-09

Completion:

2027-06-30

Conditions

• Coronary Heart Disease
• Percutaneous Coronary Intervention
• Colchicine

Interventions

• DRUG

No Results Yet

NCT06470750 | COMPLETED

75 participants

Feasibility of Patient-Centered Home Care (PCHC) to Reduce Disparities in High-Risk Black Men (BM) With Prostate Cancer (CaP)

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2024-07-25

Completion:

2025-09-29

Conditions

• Prostate Adenocarcinoma

Interventions

• OTHER

No Results Yet

NCT06468956 | COMPLETED | PHASE3

652 participants

Efficacy and Safety Study of SHR-1819 Injection in Adult Patients With Severe Atopic Dermatitis

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-06-14

Completion:

2026-08-26

Conditions

• Moderate to Severe Atopic Dermatitis

Interventions

• DRUG

No Results Yet

NCT06465953 | RECRUITING | PHASE3

48 participants

Ivosidenib (IVO) Monotherapy and Azacitidine (AZA) Monotherapy in Patients With Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS) With an IDH1 Mutation

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-12-03

Completion:

2027-11-01

Conditions

• Hypomethylating Agent (HMA) Naive Myelodysplastic Syndromes (MDS)
• Myelodysplastic Syndromes (MDS)

Interventions

• DRUG

No Results Yet

NCT06465485 | COMPLETED | PHASE3

504 participants

STEP: Phase IIIb Study of Benralizumab to Step-down Maintenance Therapy in Patients With Severe Eosinophilic Asthma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-02-28

Completion:

2026-05-13

Conditions

• Severe Eosinophilic Asthma

Interventions

• DRUG

No Results Yet

NCT06465199 | RECRUITING | PHASE1/PHASE2

265 participants

Eflornithine (DFMO) and AMXT 1501 for Neuroblastoma, CNS Tumors, and Sarcomas

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2026-05-13

Completion:

2033-05-31

Conditions

• Atypical Teratoid/Rhabdoid Tumor
• Embryonal Tumor With Multilayered Rosettes
• Ewing Sarcoma
• Diffuse Intrinsic Pontine Glioma
• Osteosarcoma
• Neuroblastoma
• DIPG Brain Tumor

Interventions

• DRUG

No Results Yet

NCT06462469 | ACTIVE_NOT_RECRUITING | PHASE4

36 participants

Study of Efficacy and Safety of Ruxolitinib in Patients With Grade II to IV Steroid-refractory Acute Graft vs. Host Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-07-04

Completion:

2026-09-02

Conditions

• Steroid-refractory Acute Graft Versus Host Disease

Interventions

• DRUG

No Results Yet

NCT06461026 | COMPLETED | PHASE1

327 participants

L9LS MAb in Malian Infants

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-08-19

Completion:

2025-06-27

Conditions

• Malaria

Interventions

• BIOLOGICAL
• OTHER

Results Available

NCT06450197 | ACTIVE_NOT_RECRUITING | PHASE2

120 participants

Phase IIa Study Evaluating AZD7798 in Crohn's Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-08-28

Completion:

2026-04-30

Conditions

• Moderate to Severe Crohn's Disease

Interventions

• DRUG
• OTHER

No Results Yet

NCT06447246 | ENROLLING_BY_INVITATION

90 participants

Respiratory Effects of Obesity in Children: Longitudinal Consequences After 6 Years of Aging

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2024-08-23

Completion:

2029-08-31

Conditions

• Childhood Obesity

No Results Yet

NCT06447025 | RECRUITING | PHASE2

85 participants

An Open-Label Study of CTI-1601 in Subjects With Friedreich's Ataxia

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-01-25

Completion:

2027-01-31

Conditions

• Friedreich Ataxia

Interventions

• DRUG

No Results Yet

NCT06445972 | RECRUITING | PHASE1/PHASE2

210 participants

Substudy 06D: Combination Therapies in Second Line (2L) Gastroesophageal Adenocarcinoma (MK-3475-06D/Keymaker-U06)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-08-07

Completion:

2028-05-09

Conditions

• Gastroesophageal Junction
• Gastroesophageal Adenocarcinoma
• Esophageal Neoplasms
• Esophageal Cancer

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT06445348 | NOT_YET_RECRUITING

80 participants

Analysis of Sub Axial Cervical Pedicle Spine Based on CT

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2026-12-30

Completion:

2027-05-21

Conditions

• Cervical Pedicle Screw

Interventions

• DEVICE

No Results Yet

NCT06442514 | NOT_YET_RECRUITING | NA

220 participants

Pain and Smoking Study 2

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2026-09-16

Completion:

2028-05-31

Conditions

• Smoking
• Pain
• Smoking Cessation

Interventions

• BEHAVIORAL
• OTHER

No Results Yet

NCT06439706 | COMPLETED | NA

108 participants

HPV Self-sampling for Underscreened Latinas

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2023-10-04

Completion:

2024-09-30

Conditions

• Uterine Cervical Neoplasm

Interventions

• BEHAVIORAL

No Results Yet

NCT06430554 | RECRUITING

40 participants

Personalized Ventilation Based on Ventilation-perfusion Mismatch and Lung Recruitability

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2024-06-08

Completion:

2026-12-30

Conditions

• Respiratory Distress Syndrome
• Positive-Pressure Respiration
• Mechanical Ventilation

No Results Yet

NCT06428409 | RECRUITING | PHASE1/PHASE2

220 participants

A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-06-20

Completion:

2029-10-16

Conditions

• Colorectal Cancer
• Pancreatic Ductal Adenocarcinoma
• Biliary Tract Cancer

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT06428175 | RECRUITING | NA

480 participants

Hospital-to-Home Transitional Care Interventions (H2H-TCI) Children/Youth With Special Health Care Needs (CYSHCN)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2025-08-28

Completion:

2028-08-31

Conditions

• Health Care
• Pediatrics
• Transitional Care
• Comparative Effectiveness
• Family Engagement

Interventions

• BEHAVIORAL

No Results Yet

NCT06426563 | RECRUITING | NA

150 participants

MWA vs RFA for the Treatment of Moderate-sized Benign Thyroid Nodules

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-04-15

Completion:

2027-12-31

Conditions

• Thyroid Nodule \(Benign\)
• Ablation Therapy

Interventions

• PROCEDURE

No Results Yet

NCT06423950 | RECRUITING

35 participants

Generating Novel Translational and Therapeutic Strategies Based on a Multicenter, Pediatric and AYA Evolutionary Tumor Board (pedsETB)

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2024-05-01

Completion:

2027-04-30

Conditions

• Pediatric Cancer

Interventions

• OTHER

No Results Yet

NCT06422806 | RECRUITING | PHASE3

365 participants

Measuring if Immunotherapy Plus Chemotherapy is Better Than Chemotherapy Alone for Patients With Aggressive Poorly Differentiated Sarcomas

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-09-11

Completion:

2032-04-18

Conditions

• Metastatic Dedifferentiated Liposarcoma
• Metastatic Undifferentiated Pleomorphic Sarcoma
• Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8
• Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8
• Unresectable Dedifferentiated Liposarcoma
• Unresectable Undifferentiated Pleomorphic Sarcoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT06422143 | RECRUITING | PHASE3

851 participants

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-06-10

Completion:

2029-01-12

Conditions

• Non-small Cell Lung Cancer
• NSCLC

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT06419374 | RECRUITING | PHASE3

762 participants

A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-05-24

Completion:

2028-06-30

Conditions

• Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT06418997 | COMPLETED | NA

306 participants

Cognitive Behavioral Immersion: A Randomized Control Trial of Peer-Based Coaching in the Metaverse

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-02-26

Completion:

2025-09-24

Conditions

• Depression, Anxiety

Interventions

• BEHAVIORAL

Results Available

NCT06405230 | TERMINATED | PHASE1/PHASE2

2 participants

Evaluation of Programmed Death Ligand 1 (PDL1) Response to Treatment in Extracellular Vesicles (EVs), Patient-derived Organoid (PDOs)s and Immune-marker Positron Emission Tomography (PET) Scanning in Non-small Cell Lung Cancer (NSCLC)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2025-10-10

Completion:

2026-07-13

Conditions

• Lung Cancer, Non-Small Cell

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT06397027 | RECRUITING | PHASE1

22 participants

A Phase I Study Investigating the Combination of the Ziftomenib, Venetoclax and Azacitidine in Pediatric Relapsed and Refractory Acute Leukemias

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-12-27

Completion:

2028-12-31

Conditions

• Refractory Acute Leukemia
• Pediatric Relapsed

Interventions

• DRUG

No Results Yet

NCT06395103 | RECRUITING | PHASE1/PHASE2

90 participants

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-08-16

Completion:

2029-03-31

Conditions

• B-cell Acute Lymphoblastic Leukemia
• Diffuse Large B-cell Lymphoma
• Burkitt Lymphoma
• Neuroblastoma
• Ewing Sarcoma

Interventions

• BIOLOGICAL

No Results Yet

NCT06393712 | ACTIVE_NOT_RECRUITING | PHASE2

210 participants

A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-05-17

Completion:

2027-08-09

Conditions

• Cerebral Amyloid Angiopathy

Interventions

• DRUG

No Results Yet

NCT06393374 | RECRUITING | PHASE3

1530 participants

Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-06-24

Completion:

2030-12-16

Conditions

• Triple-Negative Breast Cancer

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT06392802 | COMPLETED | NA

39 participants

Effectiveness of a Rehabilitation Exercise Plan at Home to Treat Post-stroke Patients in the Chronic Phase

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2023-03-01

Completion:

2025-02-28

Conditions

• Stroke
• Motor Disorders
• Physical Disability

Interventions

• DEVICE

No Results Yet

NCT06390592 | NOT_YET_RECRUITING | NA

24 participants

Clinical Performance of the Therapy Option FlexPoint of the PD Cycler Sleep•Safe Harmony

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2026-12-31

Completion:

2027-08-31

Conditions

• Renal Failure
• Chronic Kidney Disease

Interventions

• DEVICE

No Results Yet

NCT06370884 | RECRUITING | PHASE1

40 participants

Intestinal Microbiota Transplantation in Patients Undergoing Colon Resection

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-02-01

Completion:

2027-12-01

Conditions

• Recurrent Clostridioides Difficile Infection
• Colonic Surgery

Interventions

• DRUG

No Results Yet

NCT06363357 | COMPLETED | NA

8 participants

The Effect of a Muscle-mimicking, Fabric-type Shoulder Orthosis on Functional Movements of the Upper Limb in Patients With Neuromuscular Disorder

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-04-20

Completion:

2025-12-31

Conditions

• Muscular Dystrophy, Duchenne
• Orthotic Devices
• Upper Extremity
• Neuromuscular Diseases (NMD)
• Fascioscapulohumeral Muscular Dystrophy
• Spinal Muscular Atrophy (SMA)
• ALS (Amyotrophic Lateral Sclerosis)
• LGMD
• SCI - Spinal Cord Injury

Interventions

• DEVICE

No Results Yet

NCT06358261 | ENROLLING_BY_INVITATION | NA

100 participants

Study of a Diabetes Prevention Patient Activation Clinical Decision Support Tool

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-07-01

Completion:

2027-01-01

Conditions

• PreDiabetes
• Lifestyle, Healthy
• Activation, Patient

Interventions

• BEHAVIORAL

No Results Yet

NCT06353386 | RECRUITING | PHASE1/PHASE2

220 participants

Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-05-20

Completion:

2029-01-15

Conditions

• Prostatic Neoplasms, Castration-Resistant

Interventions

• DRUG

No Results Yet

NCT06352970 | RECRUITING

500 participants

Effects of Tuberculosis Infection on Development and Function of the Placenta

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2024-10-01

Completion:

2026-12-31

Conditions

• Pregnancy Related
• Tuberculosis Infection
• Placenta Diseases

Interventions

• OTHER

No Results Yet

NCT06348394 | RECRUITING | NA

444 participants

Intracardiac Versus Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2025-02-25

Completion:

2030-12-30

Conditions

• Left Atrial Appendage Closure

Interventions

• DEVICE

No Results Yet

NCT06343402 | RECRUITING | PHASE1

350 participants

Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-05-22

Completion:

2031-04-30

Conditions

• Non-small Cell Lung Cancer
• Metastatic Non-Small Cell Lung Cancer
• NSCLC
• KRAS G12C
• Metastatic Lung Cancer
• Advanced Lung Carcinoma

Interventions

• DRUG

No Results Yet