MedTrace Logo

Effects of Tuberculosis Infection on Development and Function of the Placenta

NCT06352970 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 500

Last updated 2025-03-17

No results posted yet for this study

Summary

The goal of this observational study is to understand how tuberculosis (TB) infection impacts the function and development of the placenta, and whether TB infection can contribute to pregnancy-related disorders through effects on the placenta.

The main questions it aims to answer are:

* Does TB infection affect the structure of the placenta?
* Does TB infection affect the function of the placenta?

Pregnant women attending delivery clinics in Addis Abeba, Ethiopia, will be enrolled and classified for TB infection using a blood-based test. We will compare the following outcomes between women with TB infection and women without TB infection:

* Pathological lesions of the placenta
* Gene and protein expression patterns linked to pregnancy-related disorders
* Infant outcome at birth and at 6 weeks after birth

Conditions

  • Pregnancy Related
  • Tuberculosis Infection
  • Placenta Diseases

Interventions

OTHER

TB infection

Outcomes will be compared with regard to result of interferon-gamma release assay test for TB infection

Sponsors & Collaborators

  • Addis Ababa University

    collaborator OTHER

  • Armauer Hansen Research Institute, Ethiopia

    collaborator OTHER

  • Lund University

    lead OTHER

Principal Investigators

  • Per Bjorkman, MD, PhD · Lund University

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-10-01
Primary Completion
2026-03-31
Completion
2027-12-31

Countries

  • Ethiopia

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06352970 on ClinicalTrials.gov