Clinical Trials

NCT06422143 | RECRUITING | PHASE3

851 participants

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-06-10

Completion:

2029-01-12

Conditions

• Non-small Cell Lung Cancer
• NSCLC

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT06419374 | RECRUITING | PHASE3

762 participants

A Study to Evaluate the Efficacy and Safety of Pegozafermin in Participants With Compensated Cirrhosis Due to MASH

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-05-24

Completion:

2028-06-30

Conditions

• Metabolic Dysfunction-Associated Steatohepatitis (MASH) / Nonalcoholic Steatohepatitis (NASH) With Compensated Cirrhosis

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT06418997 | COMPLETED | NA

306 participants

Cognitive Behavioral Immersion: A Randomized Control Trial of Peer-Based Coaching in the Metaverse

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-02-26

Completion:

2025-09-24

Conditions

• Depression, Anxiety

Interventions

• BEHAVIORAL

Results Available

NCT06405230 | TERMINATED | PHASE1/PHASE2

2 participants

Evaluation of Programmed Death Ligand 1 (PDL1) Response to Treatment in Extracellular Vesicles (EVs), Patient-derived Organoid (PDOs)s and Immune-marker Positron Emission Tomography (PET) Scanning in Non-small Cell Lung Cancer (NSCLC)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2025-10-10

Completion:

2026-07-13

Conditions

• Lung Cancer, Non-Small Cell

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT06397027 | RECRUITING | PHASE1

22 participants

A Phase I Study Investigating the Combination of the Ziftomenib, Venetoclax and Azacitidine in Pediatric Relapsed and Refractory Acute Leukemias

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-12-27

Completion:

2028-12-31

Conditions

• Refractory Acute Leukemia
• Pediatric Relapsed

Interventions

• DRUG

No Results Yet

NCT06395103 | RECRUITING | PHASE1/PHASE2

90 participants

Substudy 01A: Zilovertamab Vedotin in Pediatric and Young Adult Participants With Hematologic Malignancies or Solid Tumors (MK-9999-01A/LIGHTBEAM-U01)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-08-16

Completion:

2029-03-31

Conditions

• B-cell Acute Lymphoblastic Leukemia
• Diffuse Large B-cell Lymphoma
• Burkitt Lymphoma
• Neuroblastoma
• Ewing Sarcoma

Interventions

• BIOLOGICAL

No Results Yet

NCT06393712 | ACTIVE_NOT_RECRUITING | PHASE2

210 participants

A Phase 2 Trial of ALN-APP in Patients With Cerebral Amyloid Angiopathy

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-05-17

Completion:

2027-08-09

Conditions

• Cerebral Amyloid Angiopathy

Interventions

• DRUG

No Results Yet

NCT06393374 | RECRUITING | PHASE3

1530 participants

Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-06-24

Completion:

2030-12-16

Conditions

• Triple-Negative Breast Cancer

Interventions

• BIOLOGICAL
• DRUG

No Results Yet

NCT06392802 | COMPLETED | NA

39 participants

Effectiveness of a Rehabilitation Exercise Plan at Home to Treat Post-stroke Patients in the Chronic Phase

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2023-03-01

Completion:

2025-02-28

Conditions

• Stroke
• Motor Disorders
• Physical Disability

Interventions

• DEVICE

No Results Yet

NCT06390592 | NOT_YET_RECRUITING | NA

24 participants

Clinical Performance of the Therapy Option FlexPoint of the PD Cycler Sleep•Safe Harmony

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2026-12-31

Completion:

2027-08-31

Conditions

• Renal Failure
• Chronic Kidney Disease

Interventions

• DEVICE

No Results Yet

NCT06370884 | RECRUITING | PHASE1

40 participants

Intestinal Microbiota Transplantation in Patients Undergoing Colon Resection

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-02-01

Completion:

2027-12-01

Conditions

• Recurrent Clostridioides Difficile Infection
• Colonic Surgery

Interventions

• DRUG

No Results Yet

NCT06363357 | COMPLETED | NA

8 participants

The Effect of a Muscle-mimicking, Fabric-type Shoulder Orthosis on Functional Movements of the Upper Limb in Patients With Neuromuscular Disorder

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-04-20

Completion:

2025-12-31

Conditions

• Muscular Dystrophy, Duchenne
• Orthotic Devices
• Upper Extremity
• Neuromuscular Diseases (NMD)
• Fascioscapulohumeral Muscular Dystrophy
• Spinal Muscular Atrophy (SMA)
• ALS (Amyotrophic Lateral Sclerosis)
• LGMD
• SCI - Spinal Cord Injury

Interventions

• DEVICE

No Results Yet

NCT06358261 | ENROLLING_BY_INVITATION | NA

100 participants

Study of a Diabetes Prevention Patient Activation Clinical Decision Support Tool

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-07-01

Completion:

2027-01-01

Conditions

• PreDiabetes
• Lifestyle, Healthy
• Activation, Patient

Interventions

• BEHAVIORAL

No Results Yet

NCT06353386 | RECRUITING | PHASE1/PHASE2

220 participants

Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-05-20

Completion:

2029-01-15

Conditions

• Prostatic Neoplasms, Castration-Resistant

Interventions

• DRUG

No Results Yet

NCT06352970 | RECRUITING

500 participants

Effects of Tuberculosis Infection on Development and Function of the Placenta

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2024-10-01

Completion:

2026-12-31

Conditions

• Pregnancy Related
• Tuberculosis Infection
• Placenta Diseases

Interventions

• OTHER

No Results Yet

NCT06348394 | RECRUITING | NA

444 participants

Intracardiac Versus Transesophageal Echocardiographic Guidance for Left Atrial Appendage Occlusion

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2025-02-25

Completion:

2030-12-30

Conditions

• Left Atrial Appendage Closure

Interventions

• DEVICE

No Results Yet

NCT06343402 | RECRUITING | PHASE1

350 participants

Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-05-22

Completion:

2031-04-30

Conditions

• Non-small Cell Lung Cancer
• Metastatic Non-Small Cell Lung Cancer
• NSCLC
• KRAS G12C
• Metastatic Lung Cancer
• Advanced Lung Carcinoma

Interventions

• DRUG

No Results Yet

NCT06337318 | RECRUITING | PHASE3

600 participants

Comparing Rituximab and Mosunetuzumab Drug Treatments for People With Low Tumor Burden Follicular Lymphoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-10-23

Completion:

2032-03-31

Conditions

• Classic Follicular Lymphoma
• Follicular Lymphoma With Unusual Cytological Features

Interventions

• PROCEDURE
• BIOLOGICAL

No Results Yet

NCT06337084 | ACTIVE_NOT_RECRUITING | PHASE1

12 participants

Diagnostic Efficacy and Dosimetry of MNPR-101-DFO*-89Zr in Patients With Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-05-30

Completion:

2026-12-31

Conditions

• Solid Tumor, Adult
• Bladder Cancer
• Urothelial Carcinoma
• Triple-negative Breast Cancer
• Lung Cancer
• Colorectal Cancer
• Gastric Cancer
• Ovarian Cancer
• Pancreatic Cancer

Interventions

• DRUG
• DIAGNOSTIC_TEST

No Results Yet

NCT06327373 | WITHDRAWN | PHASE1/PHASE2

0 participants

A Feasibility Study of Supplemental Oxygen to Improve Pulmonary Hypertension in People With Intradialytic Hypoxemia

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2026-07-01

Completion:

2027-06-30

Conditions

• Pulmonary Hypertension

Interventions

• DRUG

No Results Yet

NCT06322264 | RECRUITING

220 participants

Promoting Children's Participation in Conventional X-ray Examinations

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2024-11-05

Completion:

2027-12-31

Conditions

• Heart Rate Determination
• Patient Participation

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT06318169 | RECRUITING | PHASE3

1350 participants

A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-03-13

Completion:

2029-02-28

Conditions

• Metabolic Dysfunction-Associated Steatotic Liver Disease (MASH) / Nonalcoholic Steatohepatitis (NASH) With Fibrosis

Interventions

• BIOLOGICAL
• OTHER

No Results Yet

NCT06312332 | COMPLETED | NA

14 participants

Michigan Emergency Department Improvement Collaborative (MEDIC) Alert; Pulmonary Embolism (PE)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-03-01

Completion:

2026-08-31

Conditions

• Pulmonary Embolism

Interventions

• BEHAVIORAL

No Results Yet

NCT06312176 | RECRUITING | PHASE3

1200 participants

A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-04-14

Completion:

2027-07-11

Conditions

• Breast Neoplasms

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT06300138 | RECRUITING | NA

150 participants

Antifungal Agents and Infrared Thermotherapy Alone or in Combination in the Treatment of Sporotrichosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-03-15

Completion:

2026-12-31

Conditions

• Sporotrichosis

Interventions

• DRUG
• DEVICE
• OTHER

No Results Yet

NCT06278961 | ACTIVE_NOT_RECRUITING

350 participants

Families Filming Infants Learning Movement

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2021-01-28

Completion:

2026-09-30

Conditions

• Infant Development
• Cerebral Palsy
• Motor Disorders
• Neurological Disorder

Interventions

• OTHER

No Results Yet

NCT06272968 | ACTIVE_NOT_RECRUITING

30 participants

Predicting Cognition After DBS for Parkinson's Disease 2

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2024-10-01

Completion:

2027-12-01

Conditions

• Cognitive Impairment

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT06271837 | ACTIVE_NOT_RECRUITING | PHASE2

127 participants

A Study of T-DXd as Monotherapy or in Combination With Anti-cancer Agents in Patients With Selected HER2-expressing Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-02-22

Completion:

2027-02-10

Conditions

• Advanced Solid Tumors (Excluding Gastric Cancer and Breast Cancer)

Interventions

• DRUG

No Results Yet

NCT06271291 | RECRUITING

30000 participants

Pancreatic Cancer Detection Consortium (PCDC) Prospective Cohorts

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2024-12-12

Completion:

2029-11-01

Conditions

• Pancreatic Carcinoma

Interventions

• OTHER

No Results Yet

NCT06269627 | RECRUITING | PHASE4

48 participants

Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2025-05-07

Completion:

2026-12-31

Conditions

• Alcohol Use Disorder

Interventions

• DRUG
• OTHER

No Results Yet

NCT06267859 | ENROLLING_BY_INVITATION | EARLY_PHASE1

600 participants

Development of Methods for Effective Treatment and Improvement of Common Somatic Diseases in Children

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2023-11-08

Completion:

2032-01-30

Conditions

• Respiratory Diseases
• Congenital Heart Defects

Interventions

• COMBINATION_PRODUCT

No Results Yet

NCT06252649 | RECRUITING | PHASE3

450 participants

Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-07-17

Completion:

2028-09-25

Conditions

• Metastatic Colorectal Cancer

Interventions

• DRUG

No Results Yet

NCT06245889 | RECRUITING | PHASE2

30 participants

PET Dynamics to Response-Adapted Neoadjuvant Therapy in TNBC

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2024-05-01

Completion:

2029-06-30

Conditions

• Triple Negative Breast Cancer

Interventions

• DRUG

No Results Yet

NCT06234995 | RECRUITING | PHASE4

80 participants

Cortical Electrophysiology of Response Inhibition in Parkinson's Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-08-09

Completion:

2027-09-30

Conditions

• Parkinson Disease

Interventions

• DRUG
• DEVICE

No Results Yet

NCT06232044 | SUSPENDED | PHASE1/PHASE2

88 participants

Testing the Combination of Two Approved Drugs and One Experimental Drug in Patients With Relapsed or Refractory Multiple Myeloma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2025-04-23

Completion:

2028-05-01

Conditions

• Recurrent Multiple Myeloma
• Refractory Multiple Myeloma

Interventions

• DRUG
• BIOLOGICAL
• PROCEDURE

No Results Yet

NCT06229418 | RECRUITING | NA

128 participants

Developing and Testing Drone-Delivered AEDs for Cardiac Arrests In Rural America

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2025-09-08

Completion:

2027-03-31

Conditions

• Cardiac Arrest
• Sudden Cardiac Arrest

Interventions

• OTHER

No Results Yet

NCT06228937 | RECRUITING

60 participants

Gut Microbiota in Patients With Limb Lymphedema and Recurrent Lymphangitis

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2024-02-22

Completion:

2027-10-30

Conditions

• Lymphedema
• Microbiota

Interventions

• OTHER

No Results Yet

NCT06227611 | RECRUITING

16 participants

Evaluation of Different Perimetric Grids to Detect Central Visual Field Defect in Glaucoma Patients With Reduce Ganglion Cell Layer Thickness Measured by Spectral Domain OCT.

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2021-05-04

Completion:

2022-05-04

Conditions

• Glaucoma

No Results Yet

NCT06221787 | COMPLETED | NA

80 participants

Stem Cell Derived Exosomes in the Treatment of Melasma and Its Percutaneous Penetration

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2022-04-01

Completion:

2025-08-01

Conditions

• Melasma

Interventions

• PROCEDURE

No Results Yet

NCT06206252 | COMPLETED

110 participants

Can Medical Cannabis Affect Opioid Use?

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2023-09-07

Completion:

2025-12-02

Conditions

• Chronic Pain
• Pain

Interventions

• OTHER

No Results Yet