Clinical Trials

NCT04683653 | RECRUITING | PHASE1/PHASE2

100 participants

Study of Pelvic Hypofractionated Radiotherapy in Endometrial Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-01-15

Completion:

2026-08-20

Conditions

• Endometrial Cancer

Interventions

• RADIATION
• OTHER

No Results Yet

NCT04677049 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

59 participants

Study of Niacin in Glioblastoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-03-18

Completion:

2027-12-31

Conditions

• Glioblastoma IDH (Isocitrate Dehydrogenase) Wildtype

Interventions

• DRUG

No Results Yet

NCT04676594 | ACTIVE_NOT_RECRUITING

400 participants

Genentech Validation Tool for Pulmonary Fibrosis

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2020-10-04

Completion:

2027-08-31

Conditions

• Interstitial Lung Disease

No Results Yet

NCT04657991 | ACTIVE_NOT_RECRUITING | PHASE3

257 participants

A Clinical Trial of Three Study Medicines (Encorafenib, Binimetinib, and Pembrolizumab) in Patients With Advanced or Metastatic Melanoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-01-15

Completion:

2026-10-30

Conditions

• Melanoma

Interventions

• DRUG

No Results Yet

NCT04643015 | ACTIVE_NOT_RECRUITING

21 participants

New Ways of Doing Magnetic Resonance Imaging in Children and Adults

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2020-11-18

Completion:

2026-11-18

Conditions

• Pediatric Disorder
• Adult Disease

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT04635384 | ACTIVE_NOT_RECRUITING

307 participants

Assessment of Chimerism and Relapse Post Bone Marrow/Hematopoietic Cell Transplant (HCT) Using AlloHeme Test

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2021-06-30

Completion:

2026-10-15

Conditions

• Acute Myeloid Leukemia
• Acute Lymphoblastic Leukemia
• Myelodysplastic Syndrome

No Results Yet

NCT04633252 | RECRUITING | PHASE1/PHASE2

86 participants

A Phase I/II Study of PDS01ADC With Docetaxel and Abiraterone in Adults With Metastatic Castration Sensitive and PDS01ADC With Docetaxel in Castration Resistant Prostate Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-02-23

Completion:

2026-12-31

Conditions

• Cancer Of Prostate
• Prostate Neoplasms

Interventions

• DRUG

No Results Yet

NCT04628767 | RECRUITING | PHASE2/PHASE3

131 participants

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-11-12

Completion:

2027-09-30

Conditions

• Renal Pelvis and Ureter Urothelial Carcinoma

Interventions

• PROCEDURE
• DRUG
• BIOLOGICAL

No Results Yet

NCT04624906 | ACTIVE_NOT_RECRUITING | PHASE2

63 participants

Bendamustine, Rituximab and Acalabrutinib in Waldenstrom's Macroglobulinemia

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-03-02

Completion:

2025-12-31

Conditions

• Waldenstrom Macroglobulinemia

Interventions

• DRUG

No Results Yet

NCT04620707 | COMPLETED | NA

52 participants

RGS@Home: Personalized 24/7 Home Care Post-stroke

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-11-09

Completion:

2023-08-04

Conditions

• Stroke
• Hemiparesis
• Subacute Stroke
• Chronic Stroke

Interventions

• DEVICE
• BEHAVIORAL

No Results Yet

NCT04588922 | RECRUITING | PHASE1/PHASE2

160 participants

Study of SLS009 (Formerly GFH009) a Potent Highly Selective CDK9 Inhibitor in Patients With Hematologic Malignancies and High-Risk Newly Diagnosed AML

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-05-10

Completion:

2026-12-30

Conditions

• Hematologic Malignancies

Interventions

• DRUG

No Results Yet

NCT04586023 | ACTIVE_NOT_RECRUITING | PHASE3

751 participants

Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-03-24

Completion:

2025-09-05

Conditions

• Relapsing Multiple Sclerosis

Interventions

• DRUG

No Results Yet

NCT04544449 | ACTIVE_NOT_RECRUITING | PHASE3

985 participants

A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants With Primary Progressive Multiple Sclerosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-10-26

Completion:

2025-09-17

Conditions

• Multiple Sclerosis, Primary Progressive

Interventions

• DRUG

No Results Yet

NCT04537390 | RECRUITING | NA

100 participants

Anti-mullerian Hormone Levels in Healthy Females

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2016-07-19

Completion:

2030-12-01

Conditions

• Healthy

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT04524871 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

518 participants

A Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients With Advanced Liver Cancers (Morpheus-Liver)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-11-01

Completion:

2027-07-30

Conditions

• Advanced Liver Cancers

Interventions

• DRUG

No Results Yet

NCT04493060 | COMPLETED | PHASE2

22 participants

Niraparib and Dostarlimab for the Treatment of Germline or Somatic BRCA1/2 and PALB2 Mutated Metastatic Pancreatic Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-12-28

Completion:

2023-12-07

Conditions

• Metastatic Pancreatic Ductal Adenocarcinoma
• Stage IV Pancreatic Cancer AJCC v8

Interventions

• BIOLOGICAL
• DRUG

Results Available

NCT04487249 | COMPLETED | NA

47 participants

Trial of Vision Therapy for Intermittent Exotropia

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-10-01

Completion:

2026-04-30

Conditions

• Intermittent Exotropia

Interventions

• OTHER

No Results Yet

NCT04470024 | ACTIVE_NOT_RECRUITING | PHASE1

19 participants

Phase Ib Trial of Multivalent Autophagosome Vaccine With or Without GITR Agonist, With Anti-PD-1 Immunotherapy in HNSCC

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-08-05

Completion:

2027-12-31

Conditions

• Cancer of the Head and Neck

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT04455230 | TERMINATED | PHASE1/PHASE2

3 participants

A Long Term Follow-Up Study of Fabry Disease Subjects Treated With FLT190

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-09-08

Completion:

2023-09-28

Conditions

• Fabry Disease
• Lysosomal Storage Diseases

Interventions

• GENETIC

Results Available

NCT04450927 | ENROLLING_BY_INVITATION

10000 participants

Data Collection of Standard Care and Evaluation of NHLBI Patients and Donors

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2020-06-16

Completion:

2040-12-31

Conditions

• Wide Spectrum of Diseases
• Hematologic Diseases

No Results Yet

NCT04377594 | ACTIVE_NOT_RECRUITING | NA

200 participants

Ablation of Fibrotic Areas in Patients With Persistent Atrial Fibrillation.

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-05-20

Completion:

2026-04-10

Conditions

• Atrial Fibrillation

Interventions

• PROCEDURE

No Results Yet

NCT04368234 | ACTIVE_NOT_RECRUITING

100000 participants

Duke COVID-19 Shared Data and Specimen Repository

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2020-04-18

Completion:

2027-06-30

Conditions

• COVID-19

No Results Yet

NCT04348136 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

27 participants

An Extension Study of JR-141 in Patients With Mucopolysaccharidosis Type II

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-09-01

Completion:

2030-03-31

Conditions

• Mucopolysaccharidosis II

Interventions

• DRUG

No Results Yet

NCT04301843 | ACTIVE_NOT_RECRUITING | PHASE2

131 participants

Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-09-25

Completion:

2028-10-01

Conditions

• Neuroblastoma

Interventions

• DRUG

No Results Yet

NCT04290130 | ENROLLING_BY_INVITATION | NA

100 participants

Dynamic Neural Mechanisms of Audiovisual Speech Perception

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-09-15

Completion:

2027-05-31

Conditions

• Speech Perception

Interventions

• OTHER

No Results Yet

NCT04246177 | TERMINATED | PHASE3

480 participants

Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-05-22

Completion:

2025-08-19

Conditions

• Carcinoma, Hepatocellular

Interventions

• DRUG
• BIOLOGICAL
• PROCEDURE

Results Available

NCT04203576 | ACTIVE_NOT_RECRUITING | NA

50 participants

First in Human Clinical Investigation of the FIRE1 System in Heart Failure Patients (FUTURE-HF)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-11-22

Completion:

2024-12-10

Conditions

• Heart Failure

Interventions

• DEVICE

No Results Yet

NCT04181060 | RECRUITING | PHASE3

300 participants

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-12-28

Completion:

2026-12-31

Conditions

• Advanced Lung Non-Squamous Non-Small Cell Carcinoma
• Metastatic Lung Non-Squamous Non-Small Cell Carcinoma
• Recurrent Lung Non-Squamous Non-Small Cell Carcinoma
• Stage IIIB Lung Cancer AJCC v8
• Stage IV Lung Cancer AJCC v8

Interventions

• BIOLOGICAL
• PROCEDURE
• DRUG

No Results Yet

NCT04166409 | RECRUITING | PHASE3

170 participants

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-01-31

Completion:

2030-12-31

Conditions

• Low Grade Astrocytoma
• Low Grade Glioma
• Metastatic Low Grade Astrocytoma
• Metastatic Low Grade Glioma
• WHO Grade 1 Glioma
• WHO Grade 2 Glioma

Interventions

• PROCEDURE
• DRUG
• OTHER

No Results Yet

NCT04136171 | COMPLETED | PHASE3

1438 participants

CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-03-13

Completion:

2026-03-25

Conditions

• Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

Interventions

• DRUG

No Results Yet

NCT04118712 | RECRUITING

100 participants

Pediatric Ovarian Tissue Banking - Operative Specimens From Females 0-18 Years of Age

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2016-10-18

Completion:

2030-12-31

Conditions

• Benign Cysts Ovarian
• Cystectomy
• Torsion
• Malignant Cysts Ovarian

No Results Yet

NCT04069273 | ACTIVE_NOT_RECRUITING | PHASE2

58 participants

Novel SEQUEnced Immunotherapy With Anti-angiogenesis and Chemotherapy in Advanced gastroesophageaL Adenocarcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-12-01

Completion:

2027-08-11

Conditions

• Gastric Cancer
• GastroEsophageal Cancer
• Adenocarcinoma

Interventions

• DRUG

No Results Yet

NCT04057963 | COMPLETED | NA

28 participants

The Inspiratory Muscle Training in Patients With Non-Specific Chronic Neck Pain

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-08-10

Completion:

2022-09-14

Conditions

• Neck Pain

Interventions

• OTHER

No Results Yet

NCT04040049 | TERMINATED | PHASE1/PHASE2

3 participants

A Fabry Disease Gene Therapy Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-07-08

Completion:

2023-05-02

Conditions

• Fabry Disease
• Lysosomal Storage Diseases

Interventions

• GENETIC

Results Available

NCT04035486 | ACTIVE_NOT_RECRUITING | PHASE3

587 participants

A Study of Osimertinib With or Without Chemotherapy as 1st Line Treatment in Patients With Mutated Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer (FLAURA2)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-07-02

Completion:

2023-04-03

Conditions

• Non-Small Cell Lung Cancer

Interventions

• DRUG

Results Available

NCT04031573 | COMPLETED | PHASE3

429 participants

Ivabradine for Heart Rate Control In Septic Shock

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-02-26

Completion:

2026-02-19

Conditions

• Septic Shock

Interventions

• DRUG

No Results Yet

NCT03994172 | COMPLETED | PHASE4

40 participants

Novel Combination Therapy for Osteoporosis in Men

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-07-01

Completion:

2025-06-30

Conditions

• Male Osteoporosis

Interventions

• DRUG
• DIETARY_SUPPLEMENT

Results Available

NCT03943537 | COMPLETED | PHASE2

87 participants

Effects of Intranasal Insulin on Neuroimaging Markers and Cognition in Patients With Psychotic Disorders

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-10-01

Completion:

2024-02-23

Conditions

• Psychosis
• Schizophrenia
• Schizo Affective Disorder
• Bipolar I Disorder

Interventions

• DRUG

Results Available

NCT03935581 | COMPLETED | NA

20 participants

Safety and Feasibility of ExAblate Neuro System to Perform Auto-Focusing Echo Imaging in Patients With Essential Tremor

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-04-25

Completion:

2020-04-28

Conditions

• Tremor, Essential
• Neurologic Manifestations
• Tremor

Interventions

• DEVICE

No Results Yet

NCT03905434 | SUSPENDED

45 participants

Identification of microRNAs Involved in Cerebral Collateral Regulation

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2018-08-14

Completion:

2027-12-01

Conditions

• Cerebrovascular Disorders

Interventions

• GENETIC

No Results Yet