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Identification of microRNAs Involved in Cerebral Collateral Regulation

NCT03905434 · Status: SUSPENDED · Type: OBSERVATIONAL · Enrollment: 45

Last updated 2026-09-03

No results posted yet for this study

Summary

Patients \>18 years of age presenting to Ohio State Wexner Medical Center Emergency department with stroke symptoms, within 6 hours of last know well and found to have acute anterior circulation large vessel occlusion (LVO) will be included in this study. The purpose of this study is to evaluate the differential expression of exosomal microRNAs in patients with stroke due to acute LVO as compared to healthy controls. In addition, the investigators will also evaluate the differential expression of exosomal microRNA in patients with good vs poor collateral grade.

Conditions

  • Cerebrovascular Disorders

Interventions

GENETIC

miRNA sampling

Blood samples for miRNA testing will be collected from all subjects (control and patients diagnosed with acute ischemic stroke)

Sponsors & Collaborators

  • Ohio State University

    collaborator OTHER

  • Virginia Commonwealth University

    lead OTHER

Principal Investigators

  • Shraddha Mainali, MD · Virginia Commonwealth University

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-08-14
Primary Completion
2027-12-01
Completion
2027-12-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03905434 on ClinicalTrials.gov