Clinical Trials

NCT04470024 | ACTIVE_NOT_RECRUITING | PHASE1

19 participants

Phase Ib Trial of Multivalent Autophagosome Vaccine With or Without GITR Agonist, With Anti-PD-1 Immunotherapy in HNSCC

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-08-05

Completion:

2027-12-31

Conditions

• Cancer of the Head and Neck

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT04455230 | TERMINATED | PHASE1/PHASE2

3 participants

A Long Term Follow-Up Study of Fabry Disease Subjects Treated With FLT190

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-09-08

Completion:

2023-09-28

Conditions

• Fabry Disease
• Lysosomal Storage Diseases

Interventions

• GENETIC

Results Available

NCT04450927 | ENROLLING_BY_INVITATION

10000 participants

Data Collection of Standard Care and Evaluation of NHLBI Patients and Donors

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2020-06-16

Completion:

2040-12-31

Conditions

• Wide Spectrum of Diseases
• Hematologic Diseases

No Results Yet

NCT04377594 | ACTIVE_NOT_RECRUITING | NA

200 participants

Ablation of Fibrotic Areas in Patients With Persistent Atrial Fibrillation.

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-05-20

Completion:

2026-04-10

Conditions

• Atrial Fibrillation

Interventions

• PROCEDURE

No Results Yet

NCT04368234 | ACTIVE_NOT_RECRUITING

100000 participants

Duke COVID-19 Shared Data and Specimen Repository

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2020-04-18

Completion:

2027-06-30

Conditions

• COVID-19

No Results Yet

NCT04348136 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

27 participants

An Extension Study of JR-141 in Patients With Mucopolysaccharidosis Type II

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-09-01

Completion:

2030-03-31

Conditions

• Mucopolysaccharidosis II

Interventions

• DRUG

No Results Yet

NCT04301843 | ACTIVE_NOT_RECRUITING | PHASE2

131 participants

Eflornithine (DFMO) and Etoposide for Relapsed/Refractory Neuroblastoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-09-25

Completion:

2028-10-01

Conditions

• Neuroblastoma

Interventions

• DRUG

No Results Yet

NCT04290130 | ENROLLING_BY_INVITATION | NA

100 participants

Dynamic Neural Mechanisms of Audiovisual Speech Perception

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-09-15

Completion:

2027-05-31

Conditions

• Speech Perception

Interventions

• OTHER

No Results Yet

NCT04246177 | TERMINATED | PHASE3

480 participants

Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-05-22

Completion:

2025-08-19

Conditions

• Carcinoma, Hepatocellular

Interventions

• DRUG
• BIOLOGICAL
• PROCEDURE

Results Available

NCT04203576 | ACTIVE_NOT_RECRUITING | NA

50 participants

First in Human Clinical Investigation of the FIRE1 System in Heart Failure Patients (FUTURE-HF)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-11-22

Completion:

2024-12-10

Conditions

• Heart Failure

Interventions

• DEVICE

No Results Yet

NCT04181060 | RECRUITING | PHASE3

300 participants

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-12-28

Completion:

2026-12-31

Conditions

• Advanced Lung Non-Squamous Non-Small Cell Carcinoma
• Metastatic Lung Non-Squamous Non-Small Cell Carcinoma
• Recurrent Lung Non-Squamous Non-Small Cell Carcinoma
• Stage IIIB Lung Cancer AJCC v8
• Stage IV Lung Cancer AJCC v8

Interventions

• BIOLOGICAL
• PROCEDURE
• DRUG

No Results Yet

NCT04166409 | RECRUITING | PHASE3

170 participants

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-01-31

Completion:

2030-12-31

Conditions

• Low Grade Astrocytoma
• Low Grade Glioma
• Metastatic Low Grade Astrocytoma
• Metastatic Low Grade Glioma
• WHO Grade 1 Glioma
• WHO Grade 2 Glioma

Interventions

• PROCEDURE
• DRUG
• OTHER

No Results Yet

NCT04136171 | COMPLETED | PHASE3

1438 participants

CARDIO-TTRansform: A Study to Evaluate the Efficacy and Safety of Eplontersen (Formerly Known as ION-682884, IONIS-TTR-LRx and AKCEA-TTR-LRx) in Participants With Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-03-13

Completion:

2026-03-25

Conditions

• Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM)

Interventions

• DRUG

No Results Yet

NCT04118712 | RECRUITING

100 participants

Pediatric Ovarian Tissue Banking - Operative Specimens From Females 0-18 Years of Age

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2016-10-18

Completion:

2030-12-31

Conditions

• Benign Cysts Ovarian
• Cystectomy
• Torsion
• Malignant Cysts Ovarian

No Results Yet

NCT04069273 | ACTIVE_NOT_RECRUITING | PHASE2

58 participants

Novel SEQUEnced Immunotherapy With Anti-angiogenesis and Chemotherapy in Advanced gastroesophageaL Adenocarcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2020-12-01

Completion:

2027-08-11

Conditions

• Gastric Cancer
• GastroEsophageal Cancer
• Adenocarcinoma

Interventions

• DRUG

No Results Yet

NCT04057963 | COMPLETED | NA

28 participants

The Inspiratory Muscle Training in Patients With Non-Specific Chronic Neck Pain

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-08-10

Completion:

2022-09-14

Conditions

• Neck Pain

Interventions

• OTHER

No Results Yet

NCT04040049 | TERMINATED | PHASE1/PHASE2

3 participants

A Fabry Disease Gene Therapy Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-07-08

Completion:

2023-05-02

Conditions

• Fabry Disease
• Lysosomal Storage Diseases

Interventions

• GENETIC

Results Available

NCT04035486 | ACTIVE_NOT_RECRUITING | PHASE3

587 participants

A Study of Osimertinib With or Without Chemotherapy as 1st Line Treatment in Patients With Mutated Epidermal Growth Factor Receptor Non-Small Cell Lung Cancer (FLAURA2)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-07-02

Completion:

2023-04-03

Conditions

• Non-Small Cell Lung Cancer

Interventions

• DRUG

Results Available

NCT04031573 | COMPLETED | PHASE3

429 participants

Ivabradine for Heart Rate Control In Septic Shock

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-02-26

Completion:

2026-02-19

Conditions

• Septic Shock

Interventions

• DRUG

No Results Yet

NCT03994172 | COMPLETED | PHASE4

40 participants

Novel Combination Therapy for Osteoporosis in Men

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-07-01

Completion:

2025-06-30

Conditions

• Male Osteoporosis

Interventions

• DRUG
• DIETARY_SUPPLEMENT

Results Available

NCT03943537 | COMPLETED | PHASE2

87 participants

Effects of Intranasal Insulin on Neuroimaging Markers and Cognition in Patients With Psychotic Disorders

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-10-01

Completion:

2024-02-23

Conditions

• Psychosis
• Schizophrenia
• Schizo Affective Disorder
• Bipolar I Disorder

Interventions

• DRUG

Results Available

NCT03935581 | COMPLETED | NA

20 participants

Safety and Feasibility of ExAblate Neuro System to Perform Auto-Focusing Echo Imaging in Patients With Essential Tremor

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-04-25

Completion:

2020-04-28

Conditions

• Tremor, Essential
• Neurologic Manifestations
• Tremor

Interventions

• DEVICE

No Results Yet

NCT03905434 | SUSPENDED

45 participants

Identification of microRNAs Involved in Cerebral Collateral Regulation

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2018-08-14

Completion:

2027-12-01

Conditions

• Cerebrovascular Disorders

Interventions

• GENETIC

No Results Yet

NCT03898297 | COMPLETED

79 participants

Imaging mGluR5 and Synaptic Density in Psychiatric Disorders

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2017-01-11

Completion:

2024-10-08

Conditions

• Major Depressive Disorder
• Bipolar Disorder
• Healthy

Interventions

• RADIATION

No Results Yet

NCT03856372 | COMPLETED | NA

1494 participants

Hypofractionated Vs Conventional Fractionated Postmastectomy Radiotherapy for High Risk Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2018-09-01

Completion:

2022-08-30

Conditions

• Breast Cancer

Interventions

• RADIATION

No Results Yet

NCT03843463 | RECRUITING | PHASE2

88 participants

Escitalopram and Language Intervention for Subacute Aphasia

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-07-18

Completion:

2027-02-18

Conditions

• Aphasia
• Stroke

Interventions

• DRUG
• BEHAVIORAL

No Results Yet

NCT03824483 | ACTIVE_NOT_RECRUITING | PHASE2

230 participants

Study of Zanubrutinib, Obinutuzumab, and Venetoclax in Patients With Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-02-22

Completion:

2027-02-28

Conditions

• Chronic Lymphocytic Leukemia (CLL)
• Small Lymphocytic Leukemia (SLL)

Interventions

• DRUG

No Results Yet

NCT03820830 | ACTIVE_NOT_RECRUITING | PHASE3

405 participants

Palbociclib for HR Positive / HER2-negative Isolated Locoregional Recurrence of Breast Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-08-27

Completion:

2026-12-31

Conditions

• Breast Cancer Recurrent

Interventions

• DRUG

No Results Yet

NCT03811405 | COMPLETED | NA

12 participants

Physiology, Imaging and Modeling of Essential Tremor

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2021-04-01

Completion:

2025-06-01

Conditions

• Essential Tremor
• Parkinson Disease
• Dystonia

Interventions

• DEVICE

Results Available

NCT03805919 | RECRUITING

500 participants

Men at High Genetic Risk for Prostate Cancer

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2019-03-27

Completion:

2029-01-01

Conditions

• Prostatic Neoplasms

No Results Yet

NCT03779854 | ACTIVE_NOT_RECRUITING | PHASE2

45 participants

Naive T Cell Depletion for Preventing Chronic Graft-versus-Host Disease in Children and Young Adults With Blood Cancers Undergoing Donor Stem Cell Transplant

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-08-29

Completion:

2028-12-31

Conditions

• Acute Biphenotypic Leukemia
• Acute Leukemia
• Acute Leukemia of Ambiguous Lineage
• Acute Lymphoblastic Leukemia
• Acute Undifferentiated Leukemia
• Allogeneic Hematopoietic Stem Cell Transplantation Recipient
• Blastic Plasmacytoid Dendritic Cell Neoplasm
• Blasts Under 25 Percent of Bone Marrow Nucleated Cells
• Blasts Under 5 Percent of Bone Marrow Nucleated Cells
• Mixed Phenotype Acute Leukemia
• Myelodysplastic Syndrome With Excess Blasts-1
• Myelodysplastic Syndrome/Acute Myeloid Leukemia
• Burkitt Leukemia
• Chronic Monocytic Leukemia
• Lymphoblastic Lymphoma
• Mast Cell Leukemia
• Myeloproliferative Neoplasm

Interventions

• RADIATION
• DRUG
• PROCEDURE

No Results Yet

NCT03764982 | ACTIVE_NOT_RECRUITING

3793 participants

RehabNytte - A Study of Rehabilitation Processes in Specialized Care in Norway

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2019-01-02

Completion:

2021-06-01

Conditions

• Rehabilitation

No Results Yet

NCT03722420 | ACTIVE_NOT_RECRUITING | PHASE3

238 participants

Randomized Evaluation of Radotinib Versus Imatinib in Phase III Study for Efficacy With Chinese Patients (RERISE China)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2018-12-28

Completion:

2023-03-03

Conditions

• Chronic Myeloid Leukemia, Chronic Phase

Interventions

• DRUG

No Results Yet

NCT03695601 | ACTIVE_NOT_RECRUITING

2743 participants

Surveillance HeartCare® Outcomes Registry

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2018-12-28

Completion:

2026-11-30

Conditions

• Heart Transplant Rejection

Interventions

• OTHER

No Results Yet

NCT03694561 | ACTIVE_NOT_RECRUITING

20 participants

Developing a Management Approach for Patients With "Late-Onset" Pompe Disease

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2019-03-25

Completion:

2027-08-31

Conditions

• Pompe Disease
• Pompe Disease (Late-onset)
• GAA Deficiency

Interventions

• OTHER

No Results Yet

NCT03674567 | COMPLETED | PHASE1/PHASE2

323 participants

Dose Escalation and Expansion Study of FLX475 Monotherapy and in Combination With Pembrolizumab

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2018-09-25

Completion:

2024-12-31

Conditions

• Advanced Cancer

Interventions

• DRUG

Results Available

NCT03664609 | RECRUITING

5000 participants

Deep Brain Stimulation (DBS) Retrospective Outcomes Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-03

Start Date:

2019-03-12

Completion:

2028-12-31

Conditions

• Parkinson Disease
• Essential Tremor
• Dystonia

Interventions

• DEVICE

No Results Yet

NCT03659916 | COMPLETED | PHASE3

116 participants

Long Term Safety & Efficacy Study Evaluating The Effect of A4250 in Children With PFIC

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2018-09-28

Completion:

2024-02-15

Conditions

• Progressive Familial Intrahepatic Cholestasis

Interventions

• DRUG

Results Available

NCT03659617 | COMPLETED | NA

42 participants

Healing Dynamics in Human Extraction Sockets Grafted With Bio-Oss Collagen®

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2018-12-10

Completion:

2025-05-22

Conditions

• Tooth Loss

Interventions

• DEVICE

Results Available

NCT03657576 | COMPLETED | PHASE1

19 participants

Trial of C134 in Patients With Recurrent GBM

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-03

Start Date:

2019-09-23

Completion:

2024-10-25

Conditions

• Glioblastoma Multiforme of Brain
• Anaplastic Astrocytoma of Brain
• Gliosarcoma of Brain

Interventions

• BIOLOGICAL

Results Available