Clinical Trials

NCT05958121 | RECRUITING | PHASE1/PHASE2

400 participants

IMA402 T Cell-Engaging Receptor Molecule (TCER®) in Recurrent and/or Refractory Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-08-09

Completion:

2027-09-30

Conditions

• Refractory Cancer
• Recurrent Cancer
• Solid Tumor, Adult
• Cancer

Interventions

• DRUG

No Results Yet

NCT05945823 | ACTIVE_NOT_RECRUITING | PHASE2

53 participants

Phase 2 Futibatinib in Combination With PD-1 Antibody Based Standard of Care in Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-07-13

Completion:

2026-10-01

Conditions

• Locally Advanced Unresectable or Metastatic Solid Tumors Including Esophageal Cancer
• Esophageal Adenocarcinoma
• Esophageal Squamous Cell Cancer
• Siewert Type 1 GEJ Cancer
• Pancreatic Cancer

Interventions

• DRUG

No Results Yet

NCT05939414 | RECRUITING | PHASE3

450 participants

An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2024-03-12

Completion:

2028-04-25

Conditions

• Oligometastatic Prostate Cancer (OMPC)

Interventions

• DRUG

No Results Yet

NCT05936034 | RECRUITING | NA

52 participants

Comparative Study of the Quality of Life of Patients Suffering From OTOTOXICITY Due to Chemotherapy Based on Platinum Salts Fitted With a Hearing Aid Compared to Those Not Fitted.

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2024-01-04

Completion:

2027-09-04

Conditions

• Cancer
• Ototoxicity, Drug-Induced
• Quality of Life
• Hearing Disorders

Interventions

• OTHER

No Results Yet

NCT05935995 | COMPLETED | NA

42 participants

Intraoperative Assessment of Surgical Margins Using Confocal Microscopy in Comparison With Reference Extemporaneous Examination

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-11-28

Completion:

2025-06-21

Conditions

• Squamous Cell Carcinoma of Head and Neck
• Basal Cell Carcinoma of Skin

Interventions

• OTHER

No Results Yet

NCT05918523 | RECRUITING

80 participants

A Long-Term Follow-Up Study of Participants Exposed to REACT

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2023-12-11

Completion:

2028-01-31

Conditions

• Diabetic Kidney Disease
• Chronic Kidney Diseases

Interventions

• BIOLOGICAL

No Results Yet

NCT05909904 | COMPLETED | PHASE2

160 participants

A Study of Tislelizumab in Combination With Investigational Agents in Participants With Head and Neck Squamous Cell Carcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-08-02

Completion:

2025-06-17

Conditions

• Head and Neck Squamous Cell Carcinoma
• Head and Neck Cancer

Interventions

• DRUG

Results Available

NCT05904093 | RECRUITING | PHASE1

25 participants

Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2024-12-18

Completion:

2027-05-14

Conditions

• Sickle Cell Disease
• Hb-SS Disease
• Hemoglobin S
• Disease Sickle Cell Anemia
• Sickle Cell Disorders
• Hemoglobin Beta Thalassemia Disease

Interventions

• DRUG

No Results Yet

NCT05897047 | COMPLETED | NA

391 participants

The smartNTx Trial:Telemedical Management Versus Standard Aftercare in Kidney Transplant Recipients (KTR)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-05-15

Completion:

2026-04-30

Conditions

• Kidney Transplant Rejection
• Kidney Transplant Failure

Interventions

• COMBINATION_PRODUCT

No Results Yet

NCT05894343 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

13 participants

Long-term Follow-up of Glutamic Acid Decarboxylase (GAD) Gene Transfer in Parkinson's Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-05-19

Completion:

2029-10-31

Conditions

• Parkinson's Disease

Interventions

• GENETIC

No Results Yet

NCT05882344 | ENROLLING_BY_INVITATION | NA

2 participants

Cholinergic Deep Brain Stimulation for Alzheimer's Disease

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2026-11-30

Completion:

2028-10-31

Conditions

• Alzheimer Disease, Early Onset
• Dementia
• Alzheimer Disease

Interventions

• PROCEDURE
• DEVICE

No Results Yet

NCT05877599 | RECRUITING | PHASE1

45 participants

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-07-12

Completion:

2029-07-31

Conditions

• Non-small Cell Lung Cancer
• Head and Neck Squamous Cell Carcinoma
• Colorectal Carcinoma
• Pancreatic Adenocarcinoma
• Breast Cancer
• Other Solid Tumors
• Ovarian Cancer
• Myeloid Neoplasms (AML/MDS)

Interventions

• BIOLOGICAL

No Results Yet

NCT05866146 | COMPLETED | NA

40 participants

Feasibility of an Interprofessional Rehabilitation Program for Chronic Low Back Patients in the Ethiopian Health Setting

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-04-03

Completion:

2023-09-22

Conditions

• Chronic Low-back Pain

Interventions

• OTHER

No Results Yet

NCT05832281 | TERMINATED | PHASE2

6 participants

Role of CBD in Improving Alexithymia

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2024-03-12

Completion:

2025-08-31

Conditions

• Alexithymia
• HIV

Interventions

• DRUG

Results Available

NCT05773352 | ACTIVE_NOT_RECRUITING

118 participants

Perform® Humeral System - Fracture Study (PFX)

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2023-08-31

Completion:

2026-10-01

Conditions

• Traumatic Arthropathy of Shoulder
• Fracture Humerus
• Traumatic Arthritis
• Revision of Other Devices if Sufficient Bone Stock Remains

Interventions

• DEVICE

No Results Yet

NCT05759117 | RECRUITING

1000 participants

Prospective Evaluation of Patients With Pleural Effusion

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2022-09-01

Completion:

2027-03-31

Conditions

• Pleural Effusion

Interventions

• PROCEDURE

No Results Yet

NCT05758246 | RECRUITING | PHASE2

220 participants

Senolytics To slOw Progression of Sepsis (STOP-Sepsis) Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-08-23

Completion:

2027-03-30

Conditions

• Sepsis
• Acute Infection
• Organ Failure

Interventions

• DRUG

No Results Yet

NCT05757791 | COMPLETED | PHASE2

20 participants

Sodium-Glucose Cotransporter-2 Inhibitor (SGLT2) in Major Depressive Disorder (MDD)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-03-17

Completion:

2026-06-06

Conditions

• Major Depressive Disorder

Interventions

• DRUG

No Results Yet

NCT05733221 | ACTIVE_NOT_RECRUITING | NA

100 participants

3D Printed Models for Mandibular Fracture Repair

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-03-11

Completion:

2026-12-31

Conditions

• Mandible Fracture
• Maxillofacial Trauma

Interventions

• DEVICE

No Results Yet

NCT05727176 | RECRUITING | PHASE2

120 participants

Study of Futibatinib in Patients With Advanced Cholangiocarcinoma With FGFR2 Fusion or Rearrangement

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-07-05

Completion:

2026-12-31

Conditions

• Advanced Cholangiocarcinoma
• FGFR2 Fusions
• Gene Rearrangement

Interventions

• DRUG

No Results Yet

NCT05712720 | COMPLETED | PHASE2

94 participants

Study to Evaluate the Efficacy and Safety of RZ402 in Diabetic Macular Edema (DME)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-02-06

Completion:

2024-04-11

Conditions

• Diabetic Macular Edema

Interventions

• DRUG
• OTHER

Results Available

NCT05710380 | RECRUITING | NA

180 participants

MRI Risk Maps for Prostate Cancer Diagnosis Using Targeted Biopsy

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-04-26

Completion:

2029-05-01

Conditions

• Prostate Cancer
• Prostate Adenocarcinoma
• Prostate Neoplasm

Interventions

• OTHER
• RADIATION
• PROCEDURE

No Results Yet

NCT05704712 | ACTIVE_NOT_RECRUITING | NA

339 participants

Exercise Incentives for YMCA Based Exercise

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-03-15

Completion:

2027-05-31

Conditions

• Physical Inactivity

Interventions

• BEHAVIORAL

No Results Yet

NCT05685602 | SUSPENDED | PHASE1

43 participants

CA-4948 Added to Standard Chemotherapy to Treat Metastatic or Unresectable Pancreatic Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-06-12

Completion:

2027-04-30

Conditions

• Metastatic Pancreatic Ductal Adenocarcinoma
• Stage III Pancreatic Cancer AJCC v8
• Stage IV Pancreatic Cancer AJCC v8
• Unresectable Pancreatic Ductal Adenocarcinoma

Interventions

• PROCEDURE
• BIOLOGICAL
• DRUG

No Results Yet

NCT05683184 | RECRUITING | PHASE1

30 participants

OMAR Opioid Use Disorder

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-03-10

Completion:

2027-12-15

Conditions

• Healthy Control
• Opioid Use Disorder

Interventions

• DRUG

No Results Yet

NCT05672316 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

28 participants

Botensilimab, Balstilimab and Regorafenib for the Treatment of Patients With Microsatellite Stable Metastatic Colorectal Cancer Who Have Progressed on Prior Chemotherapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-05-11

Completion:

2026-04-08

Conditions

• Advanced Colorectal Adenocarcinoma
• Advanced Microsatellite Stable Colorectal Carcinoma
• Metastatic Colorectal Adenocarcinoma
• Metastatic Microsatellite Stable Colorectal Carcinoma
• Stage III Colorectal Cancer AJCC v8
• Stage IV Colorectal Cancer AJCC v8

Interventions

• BIOLOGICAL
• PROCEDURE
• DRUG

No Results Yet

NCT05668923 | RECRUITING | NA

600 participants

Speech Signals in Stuttering

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-09-21

Completion:

2027-12-31

Conditions

• Stuttering, Childhood

Interventions

• BEHAVIORAL

No Results Yet

NCT05664750 | COMPLETED | PHASE3

675 participants

Study to Compare the Efficacy and Safety of Passive Immunization With TNM002 Injection and Human Tetanus Immunoglobulin as Prophylaxis Against Tetanus

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-12-22

Completion:

2023-03-24

Conditions

• Tetanus

Interventions

• DRUG

Results Available

NCT05659953 | NOT_YET_RECRUITING | PHASE1

72 participants

LMT503 First-in-human SAD, MAD, and FE Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2027-03-01

Completion:

2027-09-01

Conditions

• Inflammatory Bowel Disease
• Colitis, Ulcerative
• Crohn Disease

Interventions

• DRUG

No Results Yet

NCT05657899 | RECRUITING | NA

200 participants

The With Or Without Olecranon K-wires Trial

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-01-01

Completion:

2029-09-01

Conditions

• Olecranon Fracture

Interventions

• PROCEDURE

No Results Yet

NCT05653037 | COMPLETED | PHASE1

32 participants

A Single Ascending Doses Phase I Study to Evaluate the Safety and Pharmacokinetics of RBD4059 in Healthy Subjects

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-03-21

Completion:

2024-10-01

Conditions

• Healthy Volunteers

Interventions

• DRUG

No Results Yet

NCT05647564 | RECRUITING | NA

25 participants

PET/CT Characterization of Treatment Resistance

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-03-06

Completion:

2026-12-01

Conditions

• Prostate Cancer

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT05646862 | RECRUITING | PHASE3

420 participants

A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-06-07

Completion:

2026-11-13

Conditions

• Breast Cancer

Interventions

• DRUG

No Results Yet

NCT05645536 | ENROLLING_BY_INVITATION | PHASE3

250 participants

Safety Extension Study for Subjects With HR+, HER2- Breast Cancer for Subjects Who Have Completed the OVELIA Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-12-28

Completion:

2030-03-31

Conditions

• Breast Cancer

Interventions

• DRUG

No Results Yet

NCT05629013 | COMPLETED | NA

280 participants

TEAMS R34 #1 After-Action Reviews in Child Welfare Services

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-07-28

Completion:

2025-05-31

Conditions

• Mental Health Issue
• Children, Adult

Interventions

• BEHAVIORAL

Results Available

NCT05627635 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

20 participants

FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-05-03

Completion:

2027-06-16

Conditions

• Metastatic Colon Adenocarcinoma
• Metastatic Colorectal Adenocarcinoma
• Metastatic Microsatellite Stable Colorectal Carcinoma
• Metastatic Rectal Adenocarcinoma
• Stage IV Colon Cancer AJCC v8
• Stage IV Colorectal Cancer AJCC v8
• Stage IV Rectal Cancer AJCC v8

Interventions

• BIOLOGICAL
• PROCEDURE
• DRUG

No Results Yet

NCT05626855 | ACTIVE_NOT_RECRUITING | PHASE3

238 participants

Long-Term Safety & Efficacy of Apitegromab in Patients With SMA Who Completed Previous Trials of Apitegromab

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-04-17

Completion:

2026-11-01

Conditions

• Spinal Muscular Atrophy
• Spinal Muscular Atrophy Type 3
• Spinal Muscular Atrophy Type 2
• SMA
• Neuromuscular Diseases
• Muscular Atrophy
• Atrophy
• Muscular Atrophy, Spinal
• Neuromuscular Manifestations
• Anti-myostatin

Interventions

• DRUG

No Results Yet

NCT05623254 | COMPLETED | NA

1 participants

Feasibility and Effectiveness of a Mindfulness Program Delivered by Web to Patients During Hospitalization and Caregivers.

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-01-02

Completion:

2023-12-31

Conditions

• Chronic Migraine; Multiple Sclerosis; Motoneuron Disease

Interventions

• OTHER

No Results Yet

NCT05604430 | ENROLLING_BY_INVITATION

500 participants

Pre-hospital Ventilation Clinical Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2022-06-30

Completion:

2030-04-30

Conditions

• Altered Mental Status
• Sepsis
• Heart Failure
• Hemorrhage
• Respiratory Distress Syndrome, Adult
• Cardiac Arrest

Interventions

• DEVICE

No Results Yet

NCT05603754 | COMPLETED | PHASE3

499 participants

Safety and Efficacy of Lorecivivint (SM04690) for the Treatment of Knee Osteoarthritis (STRIDES)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-11-18

Completion:

2024-02-20

Conditions

• Knee Osteoarthritis

Interventions

• DRUG

Results Available