Clinical Trials

NCT05653037 | COMPLETED | PHASE1

32 participants

A Single Ascending Doses Phase I Study to Evaluate the Safety and Pharmacokinetics of RBD4059 in Healthy Subjects

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-03-21

Completion:

2024-10-01

Conditions

• Healthy Volunteers

Interventions

• DRUG

No Results Yet

NCT05647564 | RECRUITING | NA

25 participants

PET/CT Characterization of Treatment Resistance

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-03-06

Completion:

2026-12-01

Conditions

• Prostate Cancer

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT05646862 | RECRUITING | PHASE3

420 participants

A Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvestrant in Participants With HR-Positive, HER2-Negative, PIK3CA Mutated, Locally Advanced or Metastatic Breast Cancer Post CDK4/6i and Endocrine Combination Therapy

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-06-07

Completion:

2026-11-13

Conditions

• Breast Cancer

Interventions

• DRUG

No Results Yet

NCT05645536 | ENROLLING_BY_INVITATION | PHASE3

250 participants

Safety Extension Study for Subjects With HR+, HER2- Breast Cancer for Subjects Who Have Completed the OVELIA Study

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-12-28

Completion:

2030-03-31

Conditions

• Breast Cancer

Interventions

• DRUG

No Results Yet

NCT05629013 | COMPLETED | NA

280 participants

TEAMS R34 #1 After-Action Reviews in Child Welfare Services

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-07-28

Completion:

2025-05-31

Conditions

• Mental Health Issue
• Children, Adult

Interventions

• BEHAVIORAL

Results Available

NCT05627635 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

20 participants

FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-05-03

Completion:

2027-06-16

Conditions

• Metastatic Colon Adenocarcinoma
• Metastatic Colorectal Adenocarcinoma
• Metastatic Microsatellite Stable Colorectal Carcinoma
• Metastatic Rectal Adenocarcinoma
• Stage IV Colon Cancer AJCC v8
• Stage IV Colorectal Cancer AJCC v8
• Stage IV Rectal Cancer AJCC v8

Interventions

• BIOLOGICAL
• PROCEDURE
• DRUG

No Results Yet

NCT05626855 | ACTIVE_NOT_RECRUITING | PHASE3

238 participants

Long-Term Safety & Efficacy of Apitegromab in Patients With SMA Who Completed Previous Trials of Apitegromab

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-04-17

Completion:

2026-11-01

Conditions

• Spinal Muscular Atrophy
• Spinal Muscular Atrophy Type 3
• Spinal Muscular Atrophy Type 2
• SMA
• Neuromuscular Diseases
• Muscular Atrophy
• Atrophy
• Muscular Atrophy, Spinal
• Neuromuscular Manifestations
• Anti-myostatin

Interventions

• DRUG

No Results Yet

NCT05623254 | COMPLETED | NA

1 participants

Feasibility and Effectiveness of a Mindfulness Program Delivered by Web to Patients During Hospitalization and Caregivers.

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-01-02

Completion:

2023-12-31

Conditions

• Chronic Migraine; Multiple Sclerosis; Motoneuron Disease

Interventions

• OTHER

No Results Yet

NCT05604430 | ENROLLING_BY_INVITATION

500 participants

Pre-hospital Ventilation Clinical Study

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2022-06-30

Completion:

2030-04-30

Conditions

• Altered Mental Status
• Sepsis
• Heart Failure
• Hemorrhage
• Respiratory Distress Syndrome, Adult
• Cardiac Arrest

Interventions

• DEVICE

No Results Yet

NCT05603754 | COMPLETED | PHASE3

499 participants

Safety and Efficacy of Lorecivivint (SM04690) for the Treatment of Knee Osteoarthritis (STRIDES)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-11-18

Completion:

2024-02-20

Conditions

• Knee Osteoarthritis

Interventions

• DRUG

Results Available

NCT05577819 | RECRUITING | NA

515 participants

Prevalence and Prediction of ATTR in Ambulatory Patients With HFpEF

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2020-10-02

Completion:

2026-07-17

Conditions

• Transthyretin Amyloidosis
• Heart Failure
• Heart Failure, Diastolic
• Amyloidosis

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT05563948 | SUSPENDED | PHASE2

100 participants

Repeated Administration of Cannabis Varying in THC and CBD

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2026-10-01

Completion:

2032-09-30

Conditions

• Cannabis

Interventions

• DRUG

No Results Yet

NCT05562947 | ACTIVE_NOT_RECRUITING | PHASE3

68 participants

A Study of the Efficacy, Safety, and Pharmacokinetics (PK) of the Port Delivery System With Ranibizumab (PDS) in Chinese Participants With Neovascular Age-related Macular Degeneration (nAMD)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2024-06-17

Completion:

2027-06-30

Conditions

• Neovascular Age-related Macular Degeneration
• nAMD

Interventions

• DEVICE
• DRUG

No Results Yet

NCT05538130 | ACTIVE_NOT_RECRUITING | PHASE1

148 participants

A Study to Learn About the Study Medicine Called PF-07799544 as Monotherapy or in Combination in People With Advanced Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-11-30

Completion:

2027-08-31

Conditions

• Melanoma
• Glioma
• Thyroid Cancer
• Non-Small Cell Lung Cancer
• Malignant Neoplasms
• Brain Neoplasms
• Advanced or Metastatic Solid Tumors
• HGG
• LGG
• Low Grade Glioma
• High Grade Glioma
• Differentiated Thyroid Cancer
• NSCLC (Non-small Cell Lung Cancer)

Interventions

• DRUG

No Results Yet

NCT05538000 | ACTIVE_NOT_RECRUITING | NA

50 participants

Personalized Preventive Support for Cognitive Impairment in Non-Metastatic Breast Cancer (EFACog)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2024-08-01

Completion:

2026-08-20

Conditions

• No Metastatic Breast Cancer

Interventions

• OTHER

No Results Yet

NCT05526443 | RECRUITING

1500 participants

Austrian Registry for Evaluation of Treatment Patterns and Outcome in Patients With Advanced Pancreatic Ductal Adenocarcinoma (PDAC)

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2023-01-13

Completion:

2027-12-31

Conditions

• Pancreatic Cancer
• Advanced Pancreatic Carcinoma

Interventions

• DRUG

No Results Yet

NCT05508867 | COMPLETED | PHASE2

203 participants

A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Physician's Choice Chemotherapy in PD-(L)1-refractory, Relapsed or Refractory Classical Hodgkin Lymphoma (MK-4280A-008)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-10-18

Completion:

2025-09-03

Conditions

• Hodgkin Lymphoma

Interventions

• BIOLOGICAL
• DRUG

Results Available

NCT05495854 | TERMINATED | NA

245 participants

New Strategy for the Detection and Treatment of Helicobacter Pylori Infections in Primary Care Guided by a Non-invasive PCR in Stool

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-02-03

Completion:

2025-10-20

Conditions

• Helicobacter Pylori Infection

Interventions

• DIAGNOSTIC_TEST

No Results Yet

NCT05468437 | ACTIVE_NOT_RECRUITING | NA

96 participants

Telenutrition for Individuals With SCI

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-06-13

Completion:

2027-03-01

Conditions

• Spinal Cord Injuries
• Obesity
• Cardiometabolic Syndrome

Interventions

• BEHAVIORAL

No Results Yet

NCT05467150 | COMPLETED | NA

29 participants

Maternal Probiotic Supplementation for Improved Outcomes in Infants of Diabetic Mothers

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-10-17

Completion:

2026-08-01

Conditions

• Infant of Diabetic Mother

Interventions

• DIETARY_SUPPLEMENT

No Results Yet

NCT05438667 | TERMINATED | EARLY_PHASE1

1 participants

TCR-T Cell Therapy on Advanced Solid Tumors

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-06-01

Completion:

2026-06-16

Conditions

• Pancreatic Cancer

Interventions

• BIOLOGICAL

No Results Yet

NCT05429736 | ACTIVE_NOT_RECRUITING | NA

28 participants

Activating Spinal Circuits to Improve Walking, Balance, Strength, and Reduce Spasticity

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-03-01

Completion:

2026-09-30

Conditions

• Incomplete Spinal Cord Injury
• Spasticity, Muscle

Interventions

• BEHAVIORAL
• DEVICE

No Results Yet

NCT05388838 | COMPLETED | NA

60 participants

Screening for Oculocerebral Lymphoma With the Phenotype of NK Cells in Patients With Uveitis

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-06-01

Completion:

2025-03-17

Conditions

• Uveitis
• Lymphoma
• NK-Cell Lymphoma

Interventions

• BIOLOGICAL

No Results Yet

NCT05378763 | SUSPENDED | PHASE3

268 participants

A Study of Poziotinib in Previously Treated Participants With Locally Advanced or Metastatic NSCLC Harboring HER2 Exon 20 Mutations

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-05-12

Completion:

2027-12-25

Conditions

• NSCLC

Interventions

• DRUG

No Results Yet

NCT05375812 | RECRUITING

85 participants

NIH Investigative Deep Phenotyping Study of Gulf War Veteran Health (Project NIH IN-DEPTH)

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2023-04-16

Completion:

2030-12-31

Conditions

• Gulf War Illness

No Results Yet

NCT05355701 | ACTIVE_NOT_RECRUITING | PHASE1

103 participants

A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-07-05

Completion:

2027-08-31

Conditions

• Melanoma
• Non-Small-Cell Lung Cancer
• Thyroid Cancer
• Glioma
• Advanced Colorectal Cancer (Part 1)

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT05330221 | ACTIVE_NOT_RECRUITING | NA

364 participants

Project 2: ACHIEVE- HF

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-01-18

Completion:

2027-06-30

Conditions

• Heart Failure
• Hypertension

Interventions

• BEHAVIORAL
• DRUG

No Results Yet

NCT05327946 | ACTIVE_NOT_RECRUITING | PHASE1

42 participants

A Study in People With Advanced Cancer to Test How Well Different Doses of BI 770371 Alone or in Combination With Ezabenlimab Are Tolerated

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-05-17

Completion:

2024-07-16

Conditions

• Solid Tumors

Interventions

• DRUG

No Results Yet

NCT05327530 | ACTIVE_NOT_RECRUITING | PHASE2

256 participants

A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-08-17

Completion:

2025-06-20

Conditions

• Locally Advanced or Metastatic Urothelial Carcinoma

Interventions

• DRUG

Results Available

NCT05322850 | RECRUITING | PHASE1/PHASE2

40 participants

Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-08-16

Completion:

2026-09-30

Conditions

• Acute Myeloid Leukemia
• Acute Lymphoid Leukemia
• Mixed Phenotype Acute Leukemia
• Acute Undifferentiated Leukemia
• Chronic Myeloid Leukemia in Myeloid Blast Crisis
• Chronic Myeloid Leukemia in Lymphoid Blast Crisis (Diagnosis)
• Chronic Myeloid Leukemia - Accelerated Phase

Interventions

• BIOLOGICAL

No Results Yet

NCT05319522 | COMPLETED | NA

11 participants

The Relationship Between Irisin and Bone Health in Individuals With Spinal Cord Injury

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-05-05

Completion:

2025-04-30

Conditions

• Spinal Cord Injury

Interventions

• BEHAVIORAL

Results Available

NCT05317728 | ACTIVE_NOT_RECRUITING | NA

175 participants

Clinical Study of a Fluid Accommodating Intraocular Lens (IOL) Design

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-03-31

Completion:

2026-11-30

Conditions

• Cataract

Interventions

• DEVICE
• PROCEDURE

No Results Yet

NCT05313321 | ACTIVE_NOT_RECRUITING

100 participants

Survival of the Insignia Stem in Total Hip Arthroplasty

Study Type:

OBSERVATIONAL

Last Updated:

2026-09-01

Start Date:

2022-03-17

Completion:

2028-03-31

Conditions

• Primary Total Hip Arthroplasty

Interventions

• DEVICE

No Results Yet

NCT05304481 | RECRUITING | PHASE2

95 participants

Efficacy and Safety of Activated T Lymphocytes (ATL) in Hepatocellular Carcinoma

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-05-14

Completion:

2027-12-31

Conditions

• Hepatocellular Carcinoma

Interventions

• BIOLOGICAL

No Results Yet

NCT05289856 | COMPLETED | PHASE2

30 participants

Cabozantinib in Combination With Avelumab in Patients Refractory to Standard Chemotherapy With Advanced Neuroendocrine Neoplasias G3 (NEN G3)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-03-28

Completion:

2025-01-03

Conditions

• Cancer

Interventions

• DRUG

No Results Yet

NCT05287321 | RECRUITING | PHASE3

58 participants

The Efficacy of Aspirin Combined With Hydroxychloroquine Treatment in High Risk Pregnancies for Preeclampsia

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-05-31

Completion:

2026-12-31

Conditions

• Preeclampsia

Interventions

• DRUG

No Results Yet

NCT05285891 | ACTIVE_NOT_RECRUITING | PHASE4

123 participants

Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2023-02-07

Completion:

2031-08-25

Conditions

• Multiple Sclerosis

Interventions

• DRUG

No Results Yet

NCT05279300 | SUSPENDED | PHASE1

480 participants

A Study of CS5001 in Patients With Advanced Solid Tumors and Lymphomas

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-03-28

Completion:

2027-06-30

Conditions

• Advanced Solid Tumor
• Advanced Lymphoma

Interventions

• DRUG
• BIOLOGICAL

No Results Yet

NCT05277948 | COMPLETED | NA

240 participants

Effect of Thumbtack Needle (TN) on Ovarian Reserve Function of Women With Diminished Ovarian Reserve (DOR)

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2021-10-18

Completion:

2025-11-28

Conditions

• Diminished Ovarian Reserve

Interventions

• OTHER

No Results Yet

NCT05276973 | ACTIVE_NOT_RECRUITING | PHASE1

25 participants

Testing the Addition of Ipatasertib to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) for Stage III or IV Epithelial Ovarian Cancer

Study Type:

INTERVENTIONAL

Last Updated:

2026-09-01

Start Date:

2022-09-08

Completion:

2025-01-30

Conditions

• Fallopian Tube Endometrioid Adenocarcinoma
• Fallopian Tube High Grade Serous Adenocarcinoma
• Ovarian Endometrioid Adenocarcinoma
• Ovarian High Grade Serous Adenocarcinoma
• Primary Peritoneal Endometrioid Adenocarcinoma
• Primary Peritoneal High Grade Serous Adenocarcinoma
• Stage III Fallopian Tube Cancer AJCC v8
• Stage III Ovarian Cancer AJCC v8
• Stage III Primary Peritoneal Cancer AJCC v8
• Stage IV Fallopian Tube Cancer AJCC v8
• Stage IV Ovarian Cancer AJCC v8
• Stage IV Primary Peritoneal Cancer AJCC v8
• Unresectable Fallopian Tube Endometrioid Adenocarcinoma
• Unresectable Fallopian Tube High Grade Serous Adenocarcinoma
• Unresectable Ovarian Endometrioid Adenocarcinoma
• Unresectable Ovarian High Grade Serous Adenocarcinoma
• Unresectable Primary Peritoneal Endometrioid Adenocarcinoma
• Unresectable Primary Peritoneal High Grade Serous Adenocarcinoma

Interventions

• PROCEDURE
• DRUG

Results Available